The use of physiological and biometric data collection devices in urban space design research has emerged as a cutting-edge approach, particularly for understanding the importance of incorporating natural elements into city living environments to promote the health and well-being of their inhabitants. This study explores state-of-the-art advanced sensor technologies, such as heart rate monitors, galvanic skin response detectors, and eye-tracking and electroencephalography devices, to collect real-time data on human interactions with nature in places where concrete predominates. By analyzing these responses, researchers can quantify the restorative and health-promoting effects of nature, which are often difficult to measure through traditional survey methods. The precision, immediacy, and integration of data obtained through these new data collection technologies have boosted experimental research in this field, allowing a more nuanced understanding of the effects and variations in individual cognitive and emotional responses and contributing relevant neuroscientific, behavioural, and psychological insights. This comprehensive view of human interactions with urban nature highlights the potential of physiological and biometric devices as a source of information from their users to optimize urban planning and policy decisions aimed at creating healthier and more liveable cities. This work also addresses challenges such as data privacy, ethical considerations, and the need for interdisciplinary collaboration. Overall, the use of these innovative technologies represents a significant advancement in the quest to harmonize urban development with the natural environment, ultimately improving the quality of life of urban populations.