Pyrimidine-2-thiols are widely used in medicinal chemistry due to a wide range of biological activity. They are precursors of important organic compounds and organometallic complexes. At the current stage of the development of organic chemistry, many basic synthetic approaches to the synthesis of 1,2,4-triazole, which exhibits high antibacterial and fungicidal activity, have been developed. The relevance of the study of 1,2,4-triazole derivatives with a pyrimidine fragment is due to the synthesis of potential antibacterial drugs with a wide spectrum of action, the search for molecular descriptors of their structure, which are important for establishing the laws of "structure - biological activity". The obtained synthetic hybrids can be promising in the search for biologically active substances with antineoplastic, antibacterial, analgesic, antidiabetic activity, antihypertensive agents and other types of biological action among this range of compounds. Absorbance was measured at 516 nm. The control was a solution of 2.00 ml of 0.1 mM DPPH solution in the presence of 2.00 ml of methanol, the standard was ascorbic acid. It is worth noting that the compound has a value of antioxidant activity = 83.86%, which exceeds the activity of the comparison drug - the natural antioxidant ascorbic acid. High activity may be associated with the presence of pharmacophore fragments - a natural absorber of pyrimidine free radicals and a Sulfur atom connected to 1,2,4 triazole.