Mangiferin is a bioactive substance extracted from the plant Mangifera indica. Mangiferin has many properties, such as antiviral, antitumor, anti-inflammatory, anti-viral qualities, among others, so it has attracted much attention as a potential drug. However, one of the problems with using mangiferin for therapeutic purposes is its poor water solubility and, consequently, low bioavailability.

However, it has been found that drug matrices such as films or fibers significantly increase the bioavailability and stability of drugs and attenuate side effects. This is also true for mangiferin: several types of drug delivery matrices have been developed in recent years.

These include nanospheres made of biodegradable and biocompatible materials, lipid-based micelles, nanoemulsions of hyaluronic acid aqueous solution, and gold nanoparticles and other systems.

Some of the delivery systems have already been tested in preclinical in vivo and in vitro trials and have shown positive effects in the treatment of cancer, kidney disease, and inflammatory diseases.

The systematization of data on drug delivery systems will accelerate their study and may develop new matrices. In this work, we have compiled information on the major systems involving mangiferin and their efficacy in disease control.

This research was funded by the Russian Science Foundation, project number 24-23-00269. Link to information about the project: https://rscf.ru/en/project/24-23-00269/