Several active principles from plants could be used to mobilize HSC stem cells from the bone marrow into the bloodstream of patients. Pharmacological stem cell mobilizers showed adverse effects in patients. Thus, those active principles from plants with antioxidant and/anti-inflammatory effects (curcuminoids, AFA bluegreen algae, resveratrol, ect), could act as stem mobilizers without inducing adverse side effects. Curcuminoids [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-2,5-dione], or AFA (Aphanizomenon flos) extract are antioxidants that increase the number of CD34+ cells by flow cytometry in peripheral blood of curcumin-treated patients. CD34 is a marker of hematological stem cells (HSC). We observed that short-term AFA-Aphanizomenon flos aquae-algae or curcuminoid supplementation in healthy subjects (powder or liquid formulation) over 48 consecutive hours enhanced peripheral CD34+ mobilization in both AFA-treated patients and curcumin-supplemented healthy patients as compared to their respective untreated controls. As a whole, the short-term supplementation over 7 and 38 consecutive days by curcuminoids (2000 mg/day) plus AFA Algae bluegreen extract (400 mg/day) enhanced CD34+ peripheral levels. Collectively, these antioxidants emerge as mobilizers agents for enhancing HSC levels into the bloodstream of healthy patients without adverse effects. Further studies will evaluate signalling pathways by which curcumin promote anti-inflammatory effects in monocytes from healthy subjects, as well as in certain diseases such as depression.