Introduction: The Zika virus emerged as a significant public health challenge in Brazil, particularly after its epidemic peak in 2016. Initially identified in Africa, Zika spread to the Americas in the mid-2010s, causing widespread concern due to its association with severe neurological complications, including microcephaly in newborns and Guillain–Barré syndrome in adults.

Methods: Secondary data were collected from the Department of Informatics of the Unified Health System (DATASUS) regarding Zika virus notifications in Brazil between January 2010 and December 2024, analyzing the number of cases by year of occurrence.

Results: Between 2010 and 2024, 497,550 cases of Zika were reported in Brazil. The peak occurred in 2016, with 277,072 cases (55.7%). In 2017 and 2018, the numbers dropped to 32,225 (6.5%) and 20,092 (4%), respectively. After an increase in 2019, with 30,800 cases (6.2%), there was another decline in 2020 and 2021, with 20,637 (4.1%) and 19,112 (3.8%) cases. In 2022, notifications rose to 34,786 (7%), followed by 22,778 (4.6%) in 2023 and 35,146 (7.1%) in 2024. The initial period (2010–2014) recorded fewer than 100 cases annually, reflecting the absence of outbreaks.

Conclusions: The data reveal a significant epidemiological dynamic of the Zika virus in Brazil. After an initial period of low notification numbers (2010-2014), the 2016 outbreak marked the peak of the epidemic, accounting for more than half of the cases recorded over the 14 years investigated. A sharp decline was observed in the following years, until a slight increase in 2019. New fluctuations occurred, with rises in 2022 and 2024. The post-2016 reduction may be associated with population immunity and public health interventions, while the occasional increases suggest seasonal or regional factors. Continuous surveillance is essential to monitor and prevent new outbreaks.