Annually, coffee production in the Dominican Republic generates 18,405 tons of byproducts such as husk, pulp, silver skin, and parchment. These residues, rich in polyphenols, offer health benefits due to their ability to alleviate disorders related to obesity, a condition characterized by excess body fat, chronic inflammation, and elevated oxidative stress in adipose tissue. These negative effects can be mitigated by the bioactive compounds found in coffee and its byproducts. This study conducts an exhaustive literature review on the impact of coffee consumption and its byproducts on obesity-related alterations and oxidative stress, enhanced through artificial intelligence. Based on Scopus searches using the keywords "Coffee Therapy", which yielded 1811 articles, downloaded in CSV format, we employed artificial intelligence and natural language processing in Python to generate thematic clusters. Subsequently, 61 articles were selected from the most representative clusters aligning with our research objectives. Chlorogenic acid, a potent antioxidant present in coffee and its byproducts, has proven to be pivotal in the observed benefits for metabolic health. Supplementation with husk extract and green coffee has been shown to significantly reduce body weight, inflammation, and improve metabolic health in obese individuals. This is largely attributed to increased antioxidant defenses, as chlorogenic acid effectively eliminates free radicals, reduces oxidative stress, and enhances insulin sensitivity, factors closely linked to the development of obesity. Moreover, coffee extracts significantly reduced lipid accumulation in 3T3-L1 cells, particularly at higher doses (400 and 800 μg/mL). Additionally, an intake of 400 mg of coffee polyphenols, primarily chlorogenic acid, can significantly improve various metabolic markers, such as glucose levels and lipid profiles. These findings support the recommendation of moderate coffee consumption, of around 2-3 twelve-ounce cups daily, for overall health benefits.