1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide: as a novel and efficient nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Fatemeh Mehdipoor; Amene Yaghoubi; Mohammad G. Dekamin; Amir Hossein Fattahi

doi:10.3390/ecsoc-20-a008

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The one-pot three component synthesis of imidazole derivatives by using of 1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide as a novel and efficient nanocatalyst

1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide: as a novel and efficient nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

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¹ Department of Chemistry, Iran University of Science and Technology, Pharmaceutical and Biologically-Active Compounds Research Laboratory, Tehran, Iran.

Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-20-a008

Abstract:

The preparation, characterization and catalytic application of a novel 1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide is described. The catalyst was characterized by nitrogen adsorption-desorption analysis, scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The thermal stability of the material was also determined by thermal gravimetric analysis (TGA). The catalytic application of 1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide nanocatalyst was then investigated in the Biginelli condensation of different aldehydes with urea and alkylacetoacetates under solvent-free conditions and at moderate temperature.

Moreover, the significant advantages of this procedure are the stability, reactivity and reusability of the catalyst, low loading of the catalyst, avoiding the use of toxic transition metals, short reaction times, high to excellent yields, easy separation and puriﬁcation of the products.

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Julio A. Seijas

11 November 2016

functionalization ester vs ether

Is it possible that you have functionalized the graphene making ethers by opening the epoxides in acidic media rather than esters? the band in your FT-IR resembles the 1730 in the graphene oxide. When 1,3,5-Tris(2-hydroxyethyl) isocyanurate is in esterified the absorption of the ester is stronger, when compared to the one of N-CO-N.