Previous Article in event
Previous Article in session
Next Article in event
Next Article in session
The reaction of malononitrile dimer with 4-methyl-2,6-dichloronicotinonitrile
*
1, 2, 3
,
1, 4
,
4
,
3
Published:
14 November 2020
by MDPI
in The 24th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
The reaction of 4-methyl-2,6-dichloronicotinonitrile with malononitrile dimer (2-amino-1,1,3-tricyanopropene) in the presence of triethylamine leads to regioselective nucleophilic substitution of the chlorine atom at position 6 and the formation of triethylammonium 2-amino-3-(4-methyl-6-chloro-5-cyanopyridin-2-yl)-1,1,3-tricyanoprop-2-en-1-ide. The structure of the product was confirmed by X-ray studies.
Keywords: 2,6-dichloronicotinonitrile, malononitrile dimer, nucleophilic substitution, triethylamine
