A series of six novel Ugi-xanthates products containing several fluorine atoms were prepared in moderate to good yields (40-92%) via a MCR of-5CR followed by SN2 in one pot process. The design of molecules with fluorine atoms is of interest in medicinal chemistry and a research line of our interest. The role of fluorine atoms in biological properties is well documented, improving bioavailability, lipophilicity and metabolic resistance in bioactive molecules. These compounds could be synthetic platforms for later transformations via free radical cyclization toward the synthesis of molecules containing heterocycle peptidomimetics.