Welcome from the Chairs

Session Chair: Chiara Gorrini

Session A. Tumor Heterogeneity and Chemoresistance

Session Chairs: Francesco Novelli, Paola Cappello

Session D. Immunotherapy: Strategies to Unleash the Anti-Tumor Response

Session Chair: Paola Nisticò

Session G. Targeting Tumor Microenvironment and TME as Therapeutical Strategy to Hit Cancer

Session Chair: Federica Marchesi

Session B. Immune Heterogeneity and Immune Evasion

Short Break: 15:20-15:40 CET

Session Chair: Peter Van Loo, Samuel Mok

Session C. Clonal Evolution and Tumor Heterogeneity

Session Chair: Stephen Wong

Session E. Novel Computational Approaches in Tumor Analyses

Short Break: 14:45-15:10 CET

Session Chair: Deepak Nagrath

Session F. Proteomics and Metabolomics to Dissect Tumor Tissue Heterogeneity

Session Chair: Christine Chio

Session H. Pre-Clinical Models to Study Cancer Heterogeneity: Emerging Technologies

Short Break: 15:00-15:20 CET

Session Chairs: Jared Burks, Sammy Ferri-Borgogno

Session I. Technological Platforms for Tumor and TME Heterogeneity Studies

CET (Central European Time - UTC+1)

Speaker

Title

10.50-11.00

Welcome from the Chairs

Session A. Tumor Heterogeneity and Chemoresistance

Session Chair: Chiara Gorrini

11.00-11.25

Invited Speaker: Chiara Gorrini

Stressing out the tumor microenvironment to uncover cancer plasticity

11.25-11.30

Q&A

11.30-11.55

Invited Speaker: Laura Conti

Toll-Like Receptor 2 Promotes Breast Cancer Progression and Resistance to Chemotherapy

11.55-12.00

Q&A

12.00-12.10

Muhlis Akman

sciforum-055970 - Metabolism dependent and independent mechanisms of resistance to cisplatin induced by C/EBP-β in non-small cell lung cancer

12.10-12.20

Fabrizio Fontana

sciforum-056067 - Deciphering the role of extracellular vesicles in the bidirectional interaction between prostate cancer and adipocytes

12.20-12.30

Christophe Girard

sciforum-056134 - Mechanical activation of the collagen receptors DDR1 and DDR2 increases dedifferentiated melanoma cell aggressiveness through an actomyosin/YAP pathway

12.30-12.40

Kristine Salmina

sciforum-056230 - Role of mitotic slippage and amoeboid giant cell in tumor microenvironment and cancer resistance

12.40-12.50

Q&A

Break 12.50-13.40

Session B. Immune Heterogeneity and Immune Evasion

Session Chair: Federica Marchesi

13.40-14.05

Invited Speaker: Federica Marchesi

14.05-14.10

Q&A

14.10-14.20

Rina Masadah

sciforum-057146 - CD133, CD47, and PD-L1 Expression in Ovarian High Grade Serous Carcinoma and Its association with Metastatic Disease

14.20-14.30

Martina Godel

sciforum-055960 - 17-β-estradiol/estrogen receptor-α is an autocrine gender-related factor predicting the response to Pembrolizumab in non-small cell lung cancer

14.30-14.40

Andrea Gelemanović

sciforum-056227 - Susceptibility of an organ to become a host for metastases correlates with the local expression of immune genes

14.40-14.50

Q&A

14.50-15.15

Invited Speaker: Suhendan Ekmekcioglu

Tumor Immune Micro Environment (TIME) in Melanoma: The Science and The Tools

15.15-15.20

Q&A

Break 15.20-15.40

Session C. Clonal Evolution and Tumor Heterogeneity

Session Chairs: Peter Van Loo, Samuel Mok

15.40-16.05

Invited Speaker: Peter Van Loo

16.05-16.10

Q&A

16.10-16.35

Invited Speaker 2: Ilse Rooman

16.35-16.40

Q&A

16.40

End of day one!

CET (Central European Time - UTC+1)

Speaker

Title

10.50-11.00

Welcome to day two!

Session D. Immunotherapy: Strategies to Unleash the Anti-Tumor Response

Session Chairs: Francesco Novelli, Paola Cappello

11.00-11.25

Invited Speaker: Giuseppina Arbore

11.25-11.30

Q&A

11.30-11.55

Invited Speaker: Paola Cappello

11.55-12.00

Q&A

12.00-12.10

Marion Curtis

sciforum-056200 - PP4 inhibition stimulates anti-tumor immunity in ovarian cancer

12.10-12.20

David Roberts

sciforum-056224 - Natural Killer Cell and CD8 T Cell Recruitment and Function Are Regulated by CD47 Expression in the Tumor Microenvironment

12.20-12.30

Silvia Brugiapaglia

sciforum-056238 - Gemcitabine-based chemotherapy rescues effector T cell response to tumor-associated antigens in pancreatic cancer patients

12.30-12.40

Q&A

Break 12.40-13.30

Session E. Novel Computational Approaches in Tumor Analyses

Session Chair: Stephen Wong

13.30-13.55

Invited Speaker: Arvind Rao

13.55-14.00

Q&A

14.00-14.25

Invited Speaker: Yvonne M. Saenger

14.25-14.30

Q&A

14.30-14.40

Vânia Palma Roberto

sciforum-057192 - Integrated Bioinformatic Analysis towards the Identification of Novel Epigenetic Biomarkers for Cancer

14.40-14.45

Q&A

Break 14.45-15.10

Session F. Proteomics and Metabolomics to Dissect Tumor Tissue Heterogeneity

Session Chair: Deepak Nagrath

15.10-15.35

Invited Speaker: Deepak Nagrath

15.35-15.40

Q&A

15.40-16.05

Invited Speaker: Vincenzo Corbo

16.05-16.10

Q&A

16.10-16.35

Invited Speaker 3: Lifeng Yang

Tracing Energy Metabolism and Exploiting Cancer Vulnerability via Diet Manipulation

16.35-16.40

Q&A

16.40

End of day two!

CET (Central European Time - UTC+1)

Speaker

Title

9.40-9.45

Welcome to day three!

Session G. Targeting Tumor Microenvironment and TME as Therapeutical Strategy to Hit Cancer

Session Chair: Paola Nisticò

9.45-10.10

Invited Speaker: Paola Nisticò

10.10-10.15

Q&A

10.15-10.25

Francesca Bianchini

sciforum-055978 - Novel αvβ6-integrin ligands conjugated with nintedanib reduce TGFβ-induced EMT of human non-small cell lung cancer

10.25-10.35

Sasi S. Senga

sciforum-055305 - Cancer a Symphony by the Hallmarks

10.35-10.45

Donatella Delle Cave

sciforum-055427 - Unraveling the contribution of L1low cancer cell-derived collagen in chemoresistance and metastasis of pancreatic cancer

10.45-10.55

Q&A

Break 10.55-11.10

11.10-11.20

Daniele Viavattene

sciforum-056124 - STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by Cancer Associated Fibroblasts

11.20-11.30

Peter W. Janes

sciforum-056266 - Targeting EphA3 receptor tyrosine kinase expression in perivascular myofibroblast-like stromal cells inhibits tumour growth

11.30-11.40

Emmanuel Snacel-Fazy

sciforum-057136 - Remodeling of the glioblastoma immune landscape by Smac mimetic GDC-0152

11.40-11.50

Q&A

11.50-12.15

Invited Speaker: Alberto Bardelli

High dose Vitamin C and inactivation of DNA repair boost colorectal cancer immunotherapy

12.15-12.20

Q&A

Break 12.20-13.20

Session H. Pre-Clinical Models to Study Cancer Heterogeneity: Emerging Technologies

Session Chair: Christine Chio

13.20-13.45

Invited Speaker: Giulia Adriani

13.45-13.50

Q&A

13.50-14.00

Riccardo Rizzo

sciforum-056180 - 3D sensing scaffold for extracellular pH mapping at single cell level: A Pre-Clinical Model to Study Cancer Heterogeneity

14.00-14.10

Shweta Johari

sciforum-056244 - Mouse Tumor Model of Major Histocompatibility Complex Class I Heterogeneity

14.10-14.20

Aurélie Soubéran

sciforum-057102 - Glioblastoma tumoroids: overview and challenges

14.20-14.30

Q&A

14.30-14.55

Invited Speaker: Christine Chio

Developing redox-based therapeutics for pancreatic cancer

14.55-15.00

Q&A

Break 15.00-15.20

Session I. Technological Platforms for Tumor and TME Heterogeneity Studies

Session Chairs: Jared Burks, Sammy Ferri-Borgogno

15.20-15.45

Invited Speaker: Bernd Bodenmiller

15.45-15.50

Q&A

15.50-16.00

Stefania Forciniti

sciforum-056178 - Emerging 3D in vitro pancreatic cancer models for tumor heterogeneity studies and personalized therapies

16.00-16.05

Q&A

16.05-16.30

Invited Speaker: Jared Burks

Through the Looking Glass

16.30-16.35

Q&A

16.35-17.00

Invited Speaker: Julienne L. Carstens

Studying the functional heterogeneity of pancreatic tumor sub-populations

17.00-17.05

Q&A

17.05-17.15

Best Presentation Awards

17.15

End of day three – closing of the conference