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Convenient synthesis of some methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4H-pyridazin-1-yl)-acetamide]alkanoates
Published:
27 November 2008
by MDPI
in The 12th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: An efficient one-pot synthesis of methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4Hpyridazin-1-yl)-acetamide]alkanoates 5a-j and dipeptides 8a-f was successfully realized starting from amino acid esters 4 and azides 3, 7, respectively. The hydrazide 6a was further reacted with selected aldehydes to give the corresponding hydrazones 9a-c.
Keywords: amino acids, dipeptide, azide coupling, dihydro-2H-pyridazin-3-one,
hydrazones
