Synthesis of Thiophene Analogues of the Tacrine Series

D. Thomae; G. Kirsch; P. Seck

doi:10.3390/ecsoc-10-01380

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Synthesis of Thiophene Analogues of the Tacrine Series

D. Thomae

^{*

1},

G. Kirsch

¹,

P. Seck

¹ Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, UFR Sci FA Université Paul Verlaine-METZ, 1 Bld Arago, F-57070 METZ, France
² Laboratoire de Chimie, Faculté des Sciences, de la Technologie et de la Communication Université Luxembourg 162a, avenue de la Faïencerie, L-1511 Luxembourg, Grand-Duché de Luxembourg

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-10-01380

Abstract: Substitued 3-amino-2-cyanothiophenes condensed with cyclic ketones afforded in 2 or 3 steps analogues of velnacrine. Condensation under Friedländer conditions gave Tacine analogues in one step.

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D. Thomae

G. Kirsch

P. Seck