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Synthesis of N-substituted-3,4,5,6-tetrachlorophthalimide using trichloroacetimidate C-C bond formation method
1 , * 2
1  Department of Mathematics and Physical Sciences, Faculty of Engineering, Suez Canal University, Port Said, Egypt
2  Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt

Abstract: A series of N-substituted-3,4,5,6-tetrachlorophthalimides were prepared by a novel sequential reaction of trichloroacetimidate 3 with C-nucleophiles in the presence of TMSOTf. The nucleophiles include arenes, alkenes and active methylene to give the imidomethylation product of 3,4,5,6-tetrachlorophthalimide 5, 7, 9 and 11, respectively.
Keywords: Tetrachlorophthalimide, novel α-glucosidase inhibitors, trichloroacetimidate, C-C bond formation, C-nucleophiles

 
 
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