A New Approach to 5-Functionalized Pyrimidine-2-Thiones

Anatoly Shutalev; Ekaterina Kishko; Natalie Sivova

doi:10.3390/ecsoc-1-02012

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New Synthetic Application of Ureidoalkylation in Heterocyclic Chemistry

A New Approach to 5-Functionalized Pyrimidine-2-Thiones

Anatoly D. Shutalev

^*,

Ekaterina A. Kishko

Natalie V. Sivova

¹ Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Avenue 86, Moscow 117571, Russia.

Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-1-02012

Abstract: A new general convenient approach to the synthesis of pyrimidine-2-thiones/ones has been developed. This approach is based on the preparation of a-tosyl and a-azido substituted thioureas and ureas followed by the reaction with sodium enolates of carbonyl compounds.

Keywords: Thioureas, ureas, aldehydes, p-toluenesulfinic acid, hydrazoic acid, amidoalkylation, C-H acids, hexahydropyrimidine-2-thiones/ones, 1,2,3,4-tetrahydropyrimidine-2-thiones/ones.

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Anatoly Shutalev

Ekaterina Kishko

Natalie Sivova