Seismic safety is one of the important aspects to be addressed while designing buildings in earthquake prone regions. The paper presents a systematic analysis and design methodology for earthquake resistant school buildings in Nepal. Linear dynamic analysis (Response Spectrum analysis) has been conducted to study the performance of these buildings under earthquake loading. Structural design has been carried out as per the Limit State Design Method. Structural analysis and design methodology is done abiding by the provisions enshrined in the Indian standards and codes, making the resultant school building structures sustainable and resilient to earthquake. The paper through a case study attempts to provide a guiding light to different stakeholders, especially in Indian subcontinent, involved in designing, planning, and execution of Earthquake-Resistant Design (EQRD) Structures. By adopting the methodology, 70 schools and 1 Library building have been constructed in earthquake affect regions of Nepal.