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Synthesis of peptidomimetics via IMCR/post-transformation strategy
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Published:
14 November 2020
by MDPI
in The 24th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
A series of three 2,5-diketopiperazine (DKP’s) were synthesized via one-pot process through the post-IMCR-transformation strategy. This strategy emphasizes the role of orthogonal bifunctional reagents in the IMCR process to increase their synthetic potential, allowing us accessing a synthetic platform from which it is possible to obtain privileged heterocyclic peptidomimetics via lactamization reaction.
Keywords: 2,5-diketopiperazine (DKP’s); Ugi-4CR/lactamization; peptidomimetics
