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Controlling the Ring-Chain Tautomeric Equilibrium of a Tetrahydroquinazoline/imine System by Steric Hindrance
Ana García-Deibe
,
Cristina Portela-García
,
Lucía Briones-Miguéns
,
Matilde Fondo
,
Jesús Sanmartín-Matalobos
*
1  Coordination and Supramolecular Chemistry Group (Suprametal), Institute of Materials (iMATUS), Department of Inorganic Chemistry, Faculty of Chemistry, Universidade de Santiago de Compostela, Avenida das Ciencias s/n, 15782 Santiago de Compostela, Spain
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
https://doi.org/10.3390/ecsoc-17-a023
Abstract: We have explored the use of steric hindrance on controlling the ring-chain tautomeric equilibrium of a tetrahydroquinazoline/imine system. Two imines, one of them having a bulky group (E)-N (3-((2-((4-methylphenylsulfonamido)methyl)phenylimino)methyl)pyridin-2-yl)pivalamide (H2L1SB) and the other one without bulky group (E)-N-(2-(2,3-dihydroxybenzylideneamino)-benzyl)-4-methylbenzenesulfonamide (H2L2SB) have been synthetised and spectroscopically studied by 1H NMR. Besides, the formation of the corresponding 1,2,3,4-tetrahydroquinazolines (H2L1TQ and H2L2TQ) was tested.
Keywords: Tetrahydroquinazoline / Imine / Pivalamide / Fenol / Tautomerism
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