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[] ATP Metabolism in RBC as Potential Biomarker for Post-Exercise Hypotension and a Therapeutic Target for Cardiovascular Drugs

1 College of Pharmacy and Department of Medicine, Dalhousie University, Halifax, NS Canada B3H 4R2
2 College of Pharmacy, Dalhousie University, Halifax, NS, Canada B3H 4R2
* Author to whom correspondence should be addressed.
20 November 2017
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Abstract

The importance of adenosine and ATP in regulating many biological functions has long been recognized, especially for their effects on the cardiovascular homeostasis which may be used for management of hypertension and cardiovascular diseases. In response to ischemia and cardiovascular injury, ATP is broken down to release adenosine. The activity of adenosine is very short lived because it is rapidly taken up by myocardial and endothelial cells, erythrocytes (RBC), and also rapidly metabolized to oxypurine metabolites and other adenine nucleotides. Extra-cellular and intracellular ATP is broken down rapidly to ADP and AMP and finally to adenosine by 5’-nucleotidase. These metabolic events are known to occur in the myocardium, endothelium as well as in RBC. Exercise has been shown to increase metabolism of ATP in the RBC which may be an important mechanism for post exercise hypotension and cardiovascular protection. The post exercise effect was greater in hypertensive than in normotensive rats. The review summarizes current evidence in support of ATP metabolism in the RBC as potential systemic biomarker for cardiovascular protection and toxicities. It also discusses the opportunities, challenges and obstacles of exploiting ATP metabolism in RBC as target for drug development.

Keywords

ATP; Adenosine; Metabolism; Exercise; Cardiovascular biomarker

Cite this article as

Yeung, P.; Akhoundi, F.; Mohammadizadeh, S.; Linderfield, B. ATP Metabolism in RBC as Potential Biomarker for Post-Exercise Hypotension and a Therapeutic Target for Cardiovascular Drugs. In Proceedings of the The 2nd International Electronic Conference on Metabolomics, 20–27 November 2017; Sciforum Electronic Conference Series, Vol. 2, 2017 ; doi:10.3390/iecm-2-04983

Presentation

Author biographies

Pollen K.F. Yeung
Pollen Yeung completed his Ph.D from University of Saskatchewan (Saskatoon, SK, Canada) and is currently Professor of Pharmacy and Medicine at Dalhousie University in Halifax, NS, Canada. He has published more than 90 peer reviewed articles in reputed journals and is currently serving as Editor-in-Chief for Cardiovascular Pharmacology Open Access, a guest Editor on a thematic issue on “Biomarkers and Metabolomics for Drug Discovery” for Metabolites, and an editorial member for Medical Sciences Monitor, Metabolites, Natural Products Chemistry and Research Open Access, Cardiovascular and Hematologic Disorders Drug Targets and Current Drug Safety.

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