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The 3rd International Symposium on Frontiers in Molecular Science - RNA Regulatory Networks

26–28 June 2019, Lisbon, Portugal
Abstract Submission
March 31st 2019
Acceptance Notification
April 12th 2019
Early Bird Registration
April 19th 2019
Covering Author Registration
May 15th 2019
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Welcome from the Chairs

Dear Colleagues,

We would like to invite you to the 3rd International Symposium on Frontiers in Molecular Science – RNA regulatory networks, to take place in the vibrant city of Lisbon (Portugal) from 26-28th June 2019. The meeting will analyze the centrality of RNA regulation in biological processes and human disease, and it will constitute an excellent opportunity for the interchange of ideas and presentation of new scientific developments in the field. We aim to discuss the many dimensions of RNA regulation in development and disease, RNA structure-function relationships, the mechanisms by which plasticity is introduced, and the role of RNA in transgenerational communication.

The symposium will also serve as unique platform for the connection between senior scientists and young researchers, and for the solid establishment of future collaborations between research groups. For those new to the field, it is also an opportunity to be introduced to the exciting developments at the forefront of molecular biology.

We expect to accommodate 200 participants with especial emphasis in the involvement of young researchers from the post-graduate to the post-doctoral level.

We look forward to seeing you in Lisbon.

Francisco J. Enguita & John Mattick

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Download the conference poster here.

Sponsored By

Conference Secretariat

Yue Chen
Celia Xu
Lucia Russo

Sponsoring Opportunities

For information regarding sponsorship and exhibition opportunities, please contact:
E-Mail: ISFMS2[email protected]

Invited Speakers

Dr. Maite Huarte

CIMA, University of Navarra, Pamplona, Spain

Research Keywords
lncRNA and P53 regulatory networks

Dr. John Mattick

Genomics England, London, UK

Research Keywords

Dr. Musa Mlhanga

University of Cape Town, South Africa

Research Keywords
ncRNAs and infection

Dr. Alena Shkumatava

Institut Curie, Paris, France

Research Keywords
lncRNAs in vertebrate development

Dr. Miguel Mano

CNC, Coimbra, Portugal

Research Keywords
miRNAs, functional genomics and cardiac regeneration

Dr. Rory Johnson

University of Bern, Bern, Switzerland

Research Keywords
Genomics of lncRNAs

Dr. Tariq Rana

University of California, San Diego, CA, USA

Research Keywords
ncRNAs and cancer

Dr. Anders Lund

Universty of Copenhagen, Denmark

Research Keywords
miRNAs and ncRNAs in cancer

Dr. Marcos Malumbres

Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Research Keywords
miRNAs and cancer

Dr. Frank Slack

Harvard Medical School, Boston MA, USA

Research Keywords
ncRNAs in cancer

Dr. Marco Marcia

EMBL, Grenoble, France

Research Keywords
HOTAIR structure

Dr. George Calin

The University of Texas MD Anderson Cancer Center, TX, USA

Conference Chairs

Prof. Dr. Francisco J Enguita

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Website Website

Prof. Dr. John Mattick

Genomics England, UK Website
University of Oxford, UK Website

Conference Committee

Dr. Rosanna Asselta

Humanitas University, Italy

Dr. Subbaya Subramanian

University of Minnesota, USA

Dr. Rory Johnson

University of Bern, Bern, Switzerland

Dr. Teresa Capriglione

Universita degli Studi di Napoli Federico II, Naples, Italy

Dr. Janusz Blasiak

University of Lodz, Lodz, Poland

Dr. Lluis Ribas

IRB Barcelona, Spain

Dr. Maite Huarte

University of Navarra, Pamplona, Spain

Dr. George Calin

The University of Texas MD Anderson Cancer Center, USA

Dr. Bin Xue

University of South Florida, USA

Dr. Mateus Webba da Silva

Ulster University, UK

Dr. Alfredo Ciccodicola

CNR, Institute of Genetics and Biophysics “A. Buzzati-Traverso”, Italy

Dr. Baohong Zhang

Centro de Investigaciones Biológicas (CSIC), Spain

Dr. Anne Catherine Prats

Inserm, Toulouse, France

Dr. Pankaj Trivedi

La Sapienza University, Rome, Italy

Prof. Dr. Maurizio Battino

University of Vigo, Vigo, Spain/ Università Politecnica delle Marche, Ancona, Italy

Conference Program

WEDNESDAY 26th June 2019

Time Events
8:00 Registration
8:45 Opening remarks

Keynote opening lecture

John Mattick: The new world of RNA biology

10:00 coffee-break

Session 1: RNA regulatory networks in cancer and other disorders (Part I)


George Calin: Role of miRNAs in myelofibrosis resistance to therapy and aggressive progression


Frank Slack: The potential for personalized microRNA therapeutics


Rory Johnson: The "weakest linc": mutated long noncoding RNAs in tumour genomes


·Anne-Claire Godet: Role of the paraspeckle and of the long non-coding RNA NEAT1 in translational control during hypoxia


Catarina Morais: Long non-protein coding RNA MVIH silencing as a therapeutic approach for glioblastoma


Vanja Todorovski: Long non-coding RNA NEAT1 - A promising mechanosensor in cancer metastasis


Lunch--Poster Session 1


Session 1: RNA regulatory networks in cancer and other disorders (Part II)


Maite Huarte: Chromatin related functions of long noncoding RNAs in the regulation of cancer pathways.


Leonard Lipovich: Primate-specific long non-coding RNA genes: causes of human disease, targets for post-genomic therapeutics.


Florian Karreth: Identification of co-amplified ceRNA genes and their role in melanoma progression.


Teresa Colombo:TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network.




Session 1: RNA regulatory networks in cancer and other disorders (Part III)


Tao Liu: The novel long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein.


Pankaj Trivedi: RNA aided immunotherapy for Epstein-Barr virus associated cancers.


Aklank Jain: Circulating miR-590-5p acts as a tumor suppressor via targeting STAT3 pathway. in non-small cell lung cancer

THURSDAY 27th June 2019

Time Event
8:45 Organization remarks
9:00-9:30 Miguel Mano: Exploring high‐throughput miRNA screening as a functional genomics tool in biomedicine
9:30-9:50 Rosemary Kiernan: NF90-Dependent Regulation of miRNA Expression in Cancer
9:50-10:10 Afshin Beheshti: Circulating miRNA signature predicts health risks associated with radiation and microgravity
10:10-10:30 Pavel Sumazin: Targeting noncoding RNAs can improve the effectiveness of radiation therapy for cancer patients
10:30 Coffee-break
11:00 Session 2: RNA structure-function relationships and signaling pathways
11:00-11:30 Marco Marcia: The core tertiary structure of a long non-coding RNA is essential for stimulation of the p53 pathway
11:30-11:50 Mihaela Rita Mihailescu: Fragile X mental retardation protein: a potential switch controlling the miR-125a-mediated translation regulation of the G quadruplex forming PSD-95 mRNA
11:50-12:10 Jeffrey Evanseck: Molecular dynamics simulations of the (G4C2)n repeat expansion within c9orf72 RNA and of its interactions with fragile-X mental retardation protein
12:10-12:30 Sara Napoli: GECPAR, a noncoding RNA typical of germinal center B cell, impacts on Wnt pathway
12:30 Lunch--Poster Session 2


Session 3: RNA regulatory networks in cell, developmental and neural biology (Part I)


Alena Shkumatava: Dissecting the in vivo functions and mechanisms of action of vertebrate lncRNAs


Marcos Malumbres: Re-wiring Pluripotency with a miRNA




Session 3: RNA regulatory networks in cell, developmental and neural biology (Part II)


Tariq Rana: TBA


Maina Bitar: The transcriptional landscape of human progenitor cell populations


Daria Aleshkina: ncRNA in mammalian oocyte and early embryo development


Carolina Cunha: MicroRNA determinants of the balance between effector and regulatory CD4+ T cells in vivo


Bus to the dinner venue


Meeting dinner

FRIDAY 28th June 2019

Time Event
8:45 Organization remarks


Session 4: RNA editing and modification


Anders Lund: New roles for old ncRNAs – tuning the ribosome


Julia Filippova: CRISPR/Cas9-mediated knockout of snorRNAs reveals previously unknown targets in human cells


Baptiste Bogard: Newly identified small nucleolar RNAs play a role in myogenic differentiation

10:10-10:30 Anelia D. Horvath: Variation, splicing and RNA editing from single cell RNA-sequencing data
10:30 Coffee-break


Session 5: Regulation of gene expression, epigenetic processes and intergenerational communication


Musa Mhlanga: Immune genes are primed for robust transcription by proximal lncRNAs located in nuclear compartments


Robert M. Martin: Single-molecule imaging of transcription at damaged chromatin


Guiseppina Pisignano: Epigenetic regulation of the imprinted GNG12-AS1/DIRAS3 locus by non-coding transcription


Dimitri Pervouchine: Integrative transcriptomic analysis suggests novel autoregulatory splicing coupled with nonsense-mediated mRNA decay


Closing session


The registration fee includes attendance of all conference sessions, morning/afternoon coffee breaks and lunches, conference bag and program book.

Participation to the conference is considered final only once the registration fees have been paid. The number of participants is limited: once the number of paid registrations reaches the maximum number of participants, unpaid registrations will be cancelled.

Please note that, in order to finalize the scientific program in due time, at least one registration by anyone of the authors, denoted as Covering Author, is required to cover the presentation and publication of any accepted abstract. Covering Author registration deadline is 15 May 2019. Your abstract will be withdrawn if your registration is not complete by this date.

Authors with multiple contributions: Please note that one author registration will cover only ONE accepted contribution. Authors presenting more than 1 contribution during the event will be charged 50 euro per additional abstract (e.g., 1 author with 2 abstracts: registration fee + 50 euro; 2 authors with 3 abstracts: 2 registration fees + 50 euro; etc.)

Certificate of Attendance: Upon request, the participants of the event will receive an electronic Certificate of Attendance by email once the event is concluded.

Conference Dinner: A Gala Dinner will be served on Thursday, 27th June. Please note that the conference fee does not include this social event. Therefore, if you plan to attend the dinner, please make sure you select this extra when registering to the conference (Price per person: €30). Other social/networking events to be announced soon!

Early Regular
Student 350.00 EUR 400.00 EUR
Post-Docs 400.00 EUR 450.00 EUR
PIs & Senior Scientists 450.00 EUR 500.00 EUR
Editorial Board Members/Guest Editors of IJMS 400.00 EUR 450.00 EUR
Early price valid until: 19/04/2019  

Cancellation policy

Cancellation of paid registration is possible under the terms listed below:

> 2 months before the conference

Full refund but 60 EUR are retained for administration

> 1 month before the conference

Refund 50% of the applying fees

> 2 weeks before the conference

Refund 25% of the applying fees

< 2 weeks before the conference

No refund

In the unlikely event that MDPI shall deem it necessary to cancel the conference, all pre-paid registration fees will be reimbursed. MDPI shall not be liable for reimbursing the cost of travel or accommodation arrangements made by individual delegates.

Photographs and/or video will be taken during the conference
By taking part in this event you grant the event organisers full rights to use the images resulting from the photography/video filming, and any reproductions or adaptations of the images for fundraising, publicity or other purposes to help achieve the conference’s aims. This might include (but is not limited to), the right to use them in their printed and online publicity, social media, press releases and funding applications.

Payment methods

Wire transfer, Credit card

Instructions for Authors


The "3rd International Symposium on Frontiers in Molecular Science – RNA regulatory networks" will accept abstracts only.

The accepted abstracts will be available online on during and after the conference. Moreover, participants will have the opportunity to contribute with a full manuscript to the special issue "RNA regulatory networks" in the journal IJMS.

To present your research at the event

  • Create an account on Sciforum if you do not have one, then click on ‘New Submission’ on the upper-right corner of the window, or by clicking on ‘Submit Abstract’ at the top of this webpage.
  • Indicate what thematic area is best suited for your research.
  • Submit an abstract in English - the word limits are: minimum 150 words and maximum 300 words.
  • The deadline to submit your abstract is 31 March 2019. You will be notified by 12 April 2019 about the acceptance for poster presentation.
  • Upon submission, you can select if you wish to also be considered for oral presentation. Following assessment by the Chairs, you will be notified by 12 April 2019 in a separate email whether your contribution has been accepted for oral presentation.
  • Please note that, in order to finalize the scientific program in due time, at least one registration by any of the authors, denoted as Covering Author, is required to cover the presentation and publication of any accepted abstract. Covering Author registration deadline is 15 May 2019. Your abstract will be withdrawn if your registration is not complete by this date.

Poster Information

Maximum poster size limited to 90 × 140cm, vertical orientation preferred. Please print your poster prior to the conference.
A plan of the poster session will be circulated later on.

Ten posters will be selected prior to the conference by the Scientific Committee, and the authors will have the opportunity to present their poster in a 5-min Flash Presentation during a special session that will take place on the first day of the conference.
The Best Poster Award will be selected and granted to one of these ten flash presentations.

Publication Opportunities

  • All accepted abstracts will be available online in Open Access form on
  • Participants of this conference are cordially invited to contribute with a full manuscript to our Special Issue "RNA regulatory networks" in the journal IJMS.
  • The submission deadline for this special issue is 31 December 2019. Conference participants will be granted a 20% discount on the publication fees. Please note that no other institutional discounts will be applicable, except from reviewers’ discount vouchers.
  • IJMS is indexed by the Science Citation Index Expanded (Web of Science), MEDLINE (PubMed), and other databases, and has an Impact Factor of 3.687 (2017).

Conference Awards

The Sponsor, IJMS, offers two Best Paper awards to our conference participants, which will be announced during the Award Ceremony on the last day of the conference.

The Awards
Best Poster Award (500€)
Posters will be selected prior to the conference by the Scientific Committee, and the authors will have the opportunity to present their poster in a 3-min Flash Presentation during a special session that will take place on the first day of the conference. Two Best Poster Awards of 500€ will be granted to two of the selected posters.

Venue, Travel and Accommodation

Beware of Unauthorized Registration and Hotel Solicitations
Note that Sciforum is the only official registration platform to register to ISFM2019, and that we are not associated with any hotel agency. While other hotel resellers and travel agencies may contact you with offers for your trip, they are not endorsed by or affiliated with ISFM2019 or Sciforum. Beware that entering into financial agreements with non-endorsed companies can have costly consequences.


Lisbon is the capital and the largest city of Portugal, with an estimated population of 505,526 within its administrative limits in an area of 100.05 km2.

Its urban area extends beyond the city's administrative limits with a population of around 2.8 million people, being the 11th-most populous urban area in the European Union. About 3 million people live in the Lisbon Metropolitan Area (which represents approximately 27% of the country's population). It is mainland Europe's westernmost capital city and the only one along the Atlantic coast. Lisbon lies in the western Iberian Peninsula on the Atlantic Ocean and the River Tagus. The westernmost areas of its metro area form the westernmost point of Continental Europe, which is known as Cabo da Roca, located in the Sintra Mountains.

Lisbon is recognized as an alpha-level global city by the Globalization and World Cities (GaWC) Study Group because of its importance in finance, commerce, media, entertainment, arts, international trade, education, and tourism. Lisbon is the only Portuguese city besides Porto to be recognized as a global city. It is one of the major economic centers on the continent, with a growing financial sector and one of the largest container ports on Europe's Atlantic coast. Additionally, Humberto Delgado Airport served 26.7 million passengers in 2017, being the busiest airport in Portugal, the 3rd busiest in the Iberian Peninsula, and the 20th busiest in Europe, and the motorway network and the high-speed rail system of Alfa Pendular links the main cities of Portugal (such as Braga, Porto, and Coimbra) to Lisbon. The city is the 9th-most-visited city in Southern Europe, after Rome, Istanbul, Barcelona, Milan, Venice, Madrid, Florence, and Athens, with 3,320,300 tourists in 2017.

Lisbon is one of the oldest cities in the world, and one of the oldest in Western Europe, predating other modern European capitals such as London, Paris, and Rome by centuries.


The conference will take place in the “Pavilion of Knowledge ”, it belongs to the initial infrastructures built up for the International Exhibition in Lisbon 1998. It has been currently re-converted into a science museum, and has an auditorium for 200 people and also space for coffee breaks and a library. The auditorium is equipped with projection and sound facilities, and specialized staff that will be located for the event. The venue is located in a modern vibrant part of Lisbon, with nice pedestrian areas and good connections to the city center by metro, that is currently been populated by a lot of technological companies. The pavilion is also very close to Lisbon Portela international airport (around 10 minutes by metro or taxi). For more information see:


Pavilhão do Conhecimento – Ciência Viva Center, Largo José Mariano Gago, nº1, Parque das Nações, 1990-073 Lisbon, Portugal


To the conference venue:

-By subway/metro: There is subway/metro service at the Lisboa Airport. To go to the venue you should take the Red Line to Gare do Oriente station.

-By train: Take the Comboios de Portugal, CP service to Gare do Oriente station.

-By bus: The closest CARRIS bus stop is the “Oceanário Lisboa”, at Alameda dos Oceanos, served by buses 26B and 728. At Gare do Oriente you can find buses 400, 705, 708, 725, 728, 744, 750, 759, 782, and 794, for more information see Carris website.

-By taxi: There are taxis just outside the Lisboa Airport. The distance between the airport and the conference venue is around 5 km and costs about 8 €.

To the city center:

- By shuttle bus: There is an Aerobus, the Lisbon Airport Transfer Bus, with regular links between airport and important points in the city center that include bus and train stations.

- By subway/metro: You can take the Red and Green Line to go from Lisbon Airport to the city center.

- By taxi: The distance between the airport and the city center is around 15 km and costs about 22 €.

Travel Insurance

Subscription to an insurance plan to protect you from the high costs of illness or accident during your stay in Portugal is a prerequisite for obtaining your visa. You should obtain adequate travel, health, and accident insurance before you depart from your country. The organizers are not responsible for personal injuries, or loss of, or damage to, private property belonging to the congress participants.


Citizens of the EU and the EFTA

Citizens of EU and EFTA countries must present valid personal identification, an ID card or a passport. No visa is required.
Regardless of their citizenship, family members of EU and EFTA citizens must present a valid passport and they must have a specific residence permit from a Schengen country (no visa required). Otherwise, a visa must be obtained.

EU Countries: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom.

EFTA Countries: Iceland, Liechtenstein, Norway, Switzerland.

Schengen Countries: Austria, Belgium, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Italy, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Slovakia, Slovenia, Spain, Sweden, Switzerland.

Citizens of the USA and Canada

No visa is required for stays of up to 90 days. However, a passport valid for at least 3 months beyond your date of departure is required (6 months recommended). Portuguese government regulations may require a return or on-going ticket or proof of funds.

Other Countries

A valid passport is required and in some cases a visa must be obtained prior to entering Portugal. For more information, check this link.

Recommended hotels

Hotel/Accommodation Address Description
Ibis Lisboa Parque das Nações RUA DO MAR VERMELHO LOTE 1 07 2 2 Nº de Registo:4710, 1990 203, Lisbon, Portugal The hotel is located in Parque das Nações in Lisbon, with places of interest such as the Lisbon International Exhibition Center, Lisbon Casino, the oceanarium, the Atlantic Pavilion, and the Vasco da Gama shopping center just a few minutes away on foot. L
TRYP Lisboa Oriente Hotel Av. D. João II, Parque das Nações, 1990-083, Lisbon, Portugal Business and leisure hotel in a modern district in Lisbon, with excellent access to the city center and Lisbon Airport.
Tivoli Oriente Av. D. João II, n.º 27 Parque das Nações, 3077 4857, Lisbon, Portugal Located in Parque das Nações, in the new Eastern area of Lisbon and just a 5-minute drive from Lisbon Airport.
Olissippo Oriente Avenida Dom João II 32 , Parque das Nacoes, 1990-083, Lisbon, Portugal The Olissippo Oriente Hotel is located at Parque das Nações in Lisbon Business District. The close proximity to the Lisbon Oceanarium, the Exhibition Center (FIL), the Altice Arena, the Vasco da Gama Shopping Center and the Lisbon Casino, as well as to se
VIP Executive Art’s Hotel Avenida D. João II, 47, 3077 4857, Lisbon, Portugal This hotel is strategically located in Parque das Nações, Lisbon's modern business center, offering easy access to several leisure, restaurant, and entertainment areas.

Social Events

Gala Dinner:

We invite you to join us at the Conference Dinner at "Espelho de agua" (water mirror in English). There will be a welcome cocktail before the dinner.

Conference Sponsors



Media partners