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Biosystems in Toxicology and Pharmacology – Current challenges

8–9 Sep 2022

Biomolecular Systems, Alternative Methods, Biodevices, Biological Response, Metallodrugs, Biological Barriers, Biomaterials, Biological Drugs, Biodetection
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Welcome from the Chairs

Abstract and Manuscript submissions after the indicated deadlines are acceptable and will be considered case-by-case according to the program of the Meeting

Biological systems and models provide essential platforms for the evaluation of drugs and toxicants. From biomolecular systems comprising enzymes or antibodies to a panoply of existing cell culture models, different bio-based systems became important tools to study toxicological and pharmacological responses. The great progresses in health care, drug development, food and environmental safety did not left behind the in vitro approaches. By the contrary, keeping pace with biological knowledge and biofabrication technologies, the expectations are high in the development of novel, multifunctional, integrated, accessible, increasingly bio-informative solutions.

This Meeting aims to stimulate the research on the development and applications of biomolecular systems. Some topics in the crossroads of Toxicology and Pharmacology are initially set to promote the exchange of ideas, and the program is open to other, innovative, concepts and practical approaches addressing issues in those fields and Molecular Biosciences in general.

Topics of interest include, but are not limited to:

- Cell culture systems replicating in vivo conditions
- Biodevices and functional tissues for disease modelling
- Target identification and network pharmaco/toxicology
- Non-animal and human-relevant approaches
- Barrier mimicking and drug delivery systems
- Bioactive compounds and materials
- Responses to mixtures, emergent pollutants, food ingredients and impurities in pharmaceuticals
- Biosensors for diagnostic, environmental and industrial applications
- Development of vaccines and cell therapies
- Integration with modelling and computational methods.

We invite all the interested in the development of new bioanalytical and research methods to share their experience and participate in this forum.

Event Chairs

ESTG-Polytechnic Institute of Leiria, Portugal

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FCT-NOVA University of Lisboa, Portugal

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FCT-University of Algarve, Portugal

DETAILS

Scientific Committee

Lake Erie College of Osteopathic Medicine

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University of Porto

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Bio
Félix Carvalho, PharmD, PhD, ERT, is Full Professor of Toxicology at the Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto (FFUP). Félix Carvalho is currently: - President of EUROTOX (Association of European Toxicologists and European Societies of Toxicology); - President of the North Regional Section of the Portuguese Order of Pharmacists; - President of the Scientific Council of FFUP; - Vice-Director of the Research Unit on Applied Molecular Biosciences (UCIBIO), Portugal; - Member of the Member of the Medicines Evaluation Committee of INFARMED. The Portuguese Authority of Medicines and Health Products. - Associate member/member of the Editorial Board of several Scientific Journals in the areas of Toxicology, Pharmacology and Pharmaceutical Sciences. During the past 30 years, Félix Carvalho has published over 450 scientific articles / book chapters, and is co-editor of the books “Toxicologia Forense“ and "Toxicologia Fundamental”. ORCID profile: https://orcid.org/0000-0003-3858-3494

University of Coimbra

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NOVA University of Lisboa

DETAILS
Bio
Mário S. Diniz has a MSc and a PhD in environmental sciences and is Assistant Professor at the Chemistry Department of the NOVA SCHOOL OF SCIENCE AND TECHNOLOGY (FCT-NOVA). He is an integrated member of the “Research Unit on Applied Molecular Biosciences (UCIBIO) and is the head of the research lab “Biotox Lab”, focused on Environmental Health, Safety and Toxicology. He is author or co-author of more than 145 articles in SCI journals, 10 book chapters, 3 articles in national peer review Journals, about 43 articles in conference proceedings (peer-reviewed) and more than 95 oral communications in scientific meetings or conferences. ORCID profile: https://orcid.org/0000-0003-1571-0366

University of Algarve

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NOVA University of Lisboa

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React4life and NRCI

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National Institute of Materials Physics

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Bio
Victor Diculescu, PhD, Senior Researcher at the National Institute of Materials Physics, Bucharest, Romania, graduated the Faculty of Physics at University of Bucharest in 1998, has a MSc degree in Biophysics at the same faculty and received the PhD in Biochemistry-Biochemical Technology in 2005 at University of Coimbra, Portugal. The main activities involve the development and surface characterization of electrodes for (bio)sensing DNA, proteins and other relevant biomarkers. ORCID profile: https://orcid.org/0000-0003-0719-8016

Invited Speakers

University of Florence (Italy),
Title: Emerging Biosensors for detecting food contaminants

DETAILS
Talk
Emerging Biosensors for detecting food contaminants
Bio
Giovanna Marrazza broad expertise includes preparation and evaluation of biosensors based on the coupling of electrochemical, optical and piezoelectric sensors with enzymes, antibodies, bacteria, Molecular Imprinted Polymers and aptamers. She also is an expert in analytical procedures suitable for use with biosensor devices, i.e. flow injection analysis, microflow systems, thick-film technology; nanodispensing technologies and Immobilization procedure of biomolecules on several supports. Techniques in molecular diagnostics (DNA extraction, polymerase chain reaction, DNA purification, protein–DNA complexes); Nanomaterials: carbon nanotubes, nanobeads, nanostructured and nanocomposite polymers. Profile: https://www.unifi.it/p-doc2-0-0-A-3f2a3d2c322e2f.html

University of Extremadura (Spain),
Title: High-affinity molecular targets of amyloid β (1-42) peptide oligomers in neurons

DETAILS
Talk
High-affinity molecular targets of amyloid β (1-42) peptide oligomers in neurons
Bio
Professor of Biochemistry and Molecular Biology of the University of Extremadura. Author of more than 170 scientific publications, largely published in JCR-indexed journals. Over 40 invited oral communications in international and national meetings of Biochemistry and Molecular Biology, and Biophysics. Present research interests: molecular mechanisms of neurodegeneration induced by amyloid-β peptides and neurotoxins, and neuroprotection agents. Profile: https://orcid.org/0000-0003-3673-7007

University of Porto (Portugal),
Tentative Title: Toxicology of the XXI century

DETAILS
Talk
Tentative Title: Toxicology of the XXI century
Bio
Félix Carvalho, PharmD, PhD, ERT, is Full Professor of Toxicology at the Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto (FFUP). Félix Carvalho is currently: - President of EUROTOX (Association of European Toxicologists and European Societies of Toxicology); - President of the North Regional Section of the Portuguese Order of Pharmacists; - President of the Scientific Council of FFUP; - Vice-Director of the Research Unit on Applied Molecular Biosciences (UCIBIO), Portugal; - Member of the Member of the Medicines Evaluation Committee of INFARMED. The Portuguese Authority of Medicines and Health Products. - Associate member/member of the Editorial Board of several Scientific Journals in the areas of Toxicology, Pharmacology and Pharmaceutical Sciences. During the past 30 years, Félix Carvalho has published over 450 scientific articles / book chapters, and is co-editor of the books “Toxicologia Forense“ and "Toxicologia Fundamental”. Profile: https://orcid.org/0000-0003-3858-3494

Colorado State University (USA),
Title: Potential applications of vanadium-based anticancer drugs for intratumoral injections

DETAILS
Talk
Potential applications of vanadium-based anticancer drugs for intratumoral injections
Bio
My interest is the fundamental chemistry and biochemistry of drugs with particular interest in vanadium and other transition metal ions as metals in medicine and their mechanisms of toxicity. My group and I have synthesized new compounds and characterized them and tested their biological properties. We have been studying the fundamental coordination chemistry of vanadium and other transition metal compounds in aqueous solution and model systems for what might occur in the varied environments of biological systems. Studies of lipid systems and micro-emulsion environments help us understand how drugs and metabolites interact and penetrate lipid interfaces. Profile: https://cranslab.colostate.edu/crans-brief-resume/

Center for Physical Sciences and Technology, Lithuania,
Title: Abilities of Graphene to Monitor Human Health

DETAILS
Talk
Title: Abilities of Graphene to Monitor Human Health
Bio
The research group performs investigations in: Development of new composites of functional nanomaterials and their electrochemical investigation; Development of conducting polymers from natural monomers and their investigation; Development of electrochemical sensors for medical, food analysis, and other applications employing natural polymers and graphene; Electrochemical investigations of cell metabolites. Profile: https://www.ftmc.lt/functional-nanomaterials-laboratory

University of Coimbra, Portugal,
Title: Models and formulations to overcome the blood-brain barrier

DETAILS
Talk
Title: Models and formulations to overcome the blood-brain barrier
Bio
Lino Silva Ferreira holds a Ph.D. in Biotechnology from the University of Coimbra (Portugal). He did postdoctoral work at INEB (Portugal) and MIT (USA) in the group of Robert Langer in the areas of stem cells and nanotechnologies. He established his research group in 2008 at the University of Coimbra. Since then is the director of the Biomaterials and Stem Cell-Based Therapeutics research group, CNC coordinator of the MIT-Portugal Program and the founder of the biotech company Matera. He is also the associate editor of Biomaterials Science Journal (RSC). In 2012, he was awarded with a prestigious European Research Council starting grant and in 2016 a prestigious ERA Chair position at the University of Coimbra. His group has interest in the development of advanced therapies for ischemic diseases. Profile: http://erachair.uc-biotech.pt

Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina,
Title: Finding new molecular targets of Copper(II) complexes on triple negative breast cancer cells using mass spectrometry-based quantitative proteomics

DETAILS
Talk
Finding new molecular targets of Copper(II) complexes on triple negative breast cancer cells using mass spectrometry-based quantitative proteomics
Bio
Ignacio León is a Associate Researcher in Centro de Química Inorgánica, a research institute from CONICET and National University of La Plata. He was born in Viedma in 1986, graduated in 2010 in Biotechnology, and completed his doctoral studies (Ph.D. in Biological Sciences) in 2015 in the National University of La Plata. From 2015 to 2016 he did a postdoctoral position in Salamanca University, Spain. In the middle of 2016 he joined Centro de Química Inorgánica as an Assistant Researcher and in 2019 he received an Associate Researcher position to work at the same institute. His research interests are mainly in the field of medicinal chemistry, especially in bioinorganic chemistry focused in the design, synthesis and biological studies of metal-based drugs as antitumor agents. He co-authored more than 55 publications and more than 75 conference presentations. Profile: https://www.conicet.gov.ar/new_scp/detalle.php?id=43308&datos_academicos=yes

RWTH Aachen University, Germany,
Title: Metal-based cancer (nano)medicine

DETAILS
Talk
Metal-based cancer (nano)medicine
Bio
Quim Peña obtained his PhD degree in Chemistry from the Universitat Autònoma de Barcelona (Spain) and the Aix-Marseille Université (France) in 2019, focused on metal-based compounds as potential chemotherapeutics. He joined the Institute for Experimental Molecular Imaging at RWTH Aachen University in 2020 as a postdoctoral researcher. His current research deals with the use of nanomedicine for improved delivery of several organic- and metal-based (pro)drugs, in order to enhance their therapeutic efficiency and minimize the associated side-effects in cancer therapies. He is also involved in the synthesis of prodrugs and drug-loaded polymeric micelles projects. Profile: https://orcid.org/0000-0001-6477-8127

Detailed Program

*Attention: Times indicated are in Central European Summer Time (CEST)

Thursday 8 September 2022

10:00 – 10:10

Welcome from the Chairs & Introduction

Biosensors and Biodevices

Chair: Victor C. Diculescu

10:10-10:40

Giovanna Marrazza - Emerging biosensors for detecting food contaminants

10:40-11:10

Madalina Barsan - Proteasome biosensors and immunosensors for new diagnostic strategies and drug therapies in various diseases

Ricardo Leote - Bienzymatic Biosensor for Pyruvate Kinase Inhibitors Screening for Cancer Treatment

11:10-11:40

Rasa Pauliukaite - Abilities of Graphene to Monitor Human Health

11:40-11:50

Coffee Break

Biomimicking and Biobarriers

Chair: Maria João Moreno

11:50-12:45

Vanessa Domingues - Structure and stability of alpha-gliadin under INFOGEST-standard conditions

Alejandro Samhan Arias - Structural characterization of caveolin-2 for generation of membrane nanodomains

Dorinda Marques da Silva - Synthetic membranes as an alternative model to animal skin to investigate dermal permeation of chlorpyrifos

Cristiana Pires - Bioavailability and biotransformation of paralytic shellfish toxins assessed by permeability assays using Caco‐2 monolayers

12:45-13:15

Lino Ferreira - Models and formulations to overcome the blood-brain barrier

13:15-14:15

Lunch

Immunomodulation

Chair: Paula Videira

14:15-14:50

Emma Browne - The cytotoxicity of phorbol 12- myristate 13-acetate and lipopolysaccharide on THP-1 cells and optimized differentiation protocol

Mariana Barbosa - Targeting immune-mediated responses to tackle GNE myopathy

Materials and Drug Delivery

Chair: Mário Diniz

14:50-15:20

Quim Peña - Metal-based cancer (nano)medicine

15:20-15:30

Coffee Break

15:30-16:20

Carlos Coelho - BSA‐PEG hydrogel: A novel protein‐ligand binding 3D matrix

Anca Aldea - Flexible sensors based on metallized electrospun polymeric fibers for sweat analysis

Alexandra Pusta - Magnetic nano-carriers for the targeted delivery of antitumor drug sorafenib

Cristiana Violante - Promotion of dermal permeation of bioactive compounds using a microneedle device

16:20-16:50

Victor C. Diculescu - Electrospining for electrochemical applications

16:50-17:00

Closing Remarks

Friday 9 September 2022

Targets and Advances in Pharmacology

Chair: Ricardo Lagoa

10:00-10:30

Carlos Gutiérrez Merino - High-affinity molecular targets of amyloid β (1-42) peptide oligomers in neurons

10:30-11:15

Arnab Banerjee - Small extracellular vesicles (sEVs) imaging for clinical applications

Sofia Viana - A voluntary, metabolic inert and animal welfare friendly tool for oral drug dosing – pill tech

Akhileshwar Srivastava - In silico screening of the therapeutic paradigm of curcuminoids relative to conventional drugs for inactivation of SARS-CoV2 receptors

11:15-11:25

Coffee Break

11:25-12:00

Poster Sessions - 2 Parallel sessions for Flash Presentations

Chairs: Dorinda Silva and Joaquim Rui Rodrigues

Session I (room 1):

Andreia Vilaça - Proteomic profiling of extracellular vesicles identifies source-specific molecular signature

Caroline Sanz - Electrochemical characterization of shikonin and in-situ evaluation of interaction with DNA

Daniela Oprea - Polymer nanofibers support for biosensing application in cell cultures

Inês Ferreira - Deep eutectic systems: What methodology should we use to assess toxicity?

Iris Correia - An insight into the nutritional profile and antioxidant activity of the sea fennel halophyte plant (Crithmum maritimum)

Session II (room 2):

Daciana Botta - Electrochemical Devices with Metallized Electrospun Fiber Meshes Electrodes

Mihaela-Cristina Bunea - Degradation of azathioprine and its effects on DNA

Magdolna Casian - Selection, characterization and use of Protein Golgi 73 specific aptamer as a tool for early-stage diagnosis of hepatocellular cancer

Gil Fraqueza - Pharmacological, Antimicrobial and Toxicological Actions of Vanadium Compounds

Magda Rodrigues - Freeze-dried small extracellular vesicles (sEVs): the next step for sEV clinical applications

Zélia Silva - Oxidative stress and inflammatory response of fibroblasts exposed to chlorpyrifos

Advances in Toxicology

Chair: Judite Vieira

12:00-12:45

Vera Costa - Cardio-oncology: something old, something new, something bowered and something blue

João Lopes - Use of lipid vesicles for revealing the potential contribution of cytochrome c in the metabolism of environmental toxicants

Inês Rodrigues - Effects of atmospheric particulate matter (PM) in exposed Mytilus galloprovincialis

12:45-13:15

Félix Carvalho - Toxicology of the XXI century

13:15-14:15

Lunch

14:15-15:15

Special Session: Environmental Health and Human Toxicology - from the Lab to the Field

Chairs: Dorinda Silva, Silvia Scaglione and Ethel Eljarrat

Metallodrugs

Chair: Manuel Aureliano

15:15-15:45

Ignacio León - Finding new molecular targets of Copper(II) complexes on triple negative breast cancer cells using mass spectrometry-based quantitative proteomics

15:45-15:55

Coffee Break

15:55-16:20

Ricardo Lagoa - The growth curve method to rapidly derive the antibacterial potential of polyoxovanadates

Diana Pereira - Silver-based nanoparticles as powerful pathogen-killing agents

16:20-16:50

Debbie C. Crans - Potential applications of vanadium-based anticancer drugs for intratumoral injections

16:50-17:00

Closing Remarks



Registration

Participation in the Meeting is considered final only when the registration fee has been paid. The number of participants is limited: once the number of paid registrations reaches the maximum number of participants, unpaid registrations will be cancelled.

Please note that, in order to define the scientific Program in due time, at least one registration by anyone of the authors, denoted as Covering Author, is required to cover the presentation and publication of any accepted abstract. Covering Author registration deadline is 8 July 2022. Your abstract will be withdrawn if your registration is not complete by this date.

Authors with multiple contributions: Please note that one author registration will cover only ONE accepted contribution.

Conference Paper - Publication Fees

As indicated in the Instructions for Authors, accepted manuscripts can optionally be published in a dedicated volume of the Journal Medical Sciences Forum. Note that publication of the accepted manuscripts will only be available for those authors that have paid the relevant publication charges. If you wish to publish your conference paper in the dedicated volume, please select one of the following Registration Extras* when placing your registration order:

- Publication of Conference Paper (1 - 4 pages): 30 Euro
- Publication of Conference Paper (1 - 9 pages): 60 Euro

Support to participation

The Organization can support some fees (Registration or Paper publication) on request until 28th July. Young students and participants from Low/Lower-Middle income countries (participant affiliation) can apply. After Abstract submission and before registration, contact the Organization: Dra. Dorinda Silva (mbstoxleiria@gmail.com).

Registration and Invoicing Contact Person

Click on "Event Registration" to register in the Meeting. The extra fees for publication of your Conference Paper in Medical Sciences Forum will appear to select as optional extras. Please do not hesitate to contact Ms. Carmen Ruiz (carmen.ruiz@mdpi.com) for any query regarding your registration order or invoice related to the event.

Regular
Until 31st August 2022
Invited Speakers and Chairs Free
General Attendance 90.00 EUR
Payment methods

Wire transfer, Credit card

Instructions for Authors

How to submit a work to the Meeting

The Meeting offers flexible opportunities to present and publish your work.

Submissions should be done by the authors online by registering at www.sciforum.net, and using the "Start New Submission" function once logged into the system. There is no limit of abstracts submitted by one author, but one registration will cover only ONE accepted contribution.

  1. Researchers interested in participating at the Meeting can submit their abstract online on this website until 30 June 2022. The abstract submitted should be in English. Late abstract submissions might also be accepted according to the limit of participants and the program planning.
  2. The Scientific Committee will evaluate the abstracts received and all the authors will be notified about the acceptance of their works before 30 June 2022.
  3. If the abstract is accepted for the Meeting, the authors will be asked to upload a "Full file" of their work (a Manuscript and/or a Slide presentation or a Video), up to the deadline of 31 August 2022. These Full files are optional, but offer the possibility to all authors to show more of their works.
  4. Following assessment by the Scientific Committee, you will be notified by 11 July 2022 whether your contribution has also been accepted for Oral Communication at the event. Late abstract submissions will be considered according to the program planning.
  5. The Abstracts and the uploaded Full files will be available at this website for discussion during the time of the Meeting, 8–9 September 2022.
  6. Optionally, authors can publish their Manuscripts as Conference Papers in a dedicated volume of the Journal Medical Sciences Forum. Note that publication of the accepted manuscripts requires payment of publication charges. The Papers will be published with a DOI and the authors retain the copyright of the work. Please refer to the below Manuscript instructions and the above Registration information for further details.

After the Meeting, participants are encouraged to submit their full work to the Special Issue of the journal International Journal of Molecular Sciences associated to the Meeting. These articles will be offered a discount over the general APC of the Journal.
Note that the submission to the Special Issue is independent from the Conference Papers and will follow the usual process of the Journal, including peer-review, etc.

Manuscript Preparation

Manuscripts for the Meeting and publication in Medical Sciences Forum must have the following organization:

First page:

  • Title
  • Full author names
  • Affiliations (including full postal address) and authors' e-mail addresses (institutional addresses preferred)
  • Abstract (200–300 words)
  • Keywords

Sections:

  • Introduction
  • Methods
  • Results and Discussion
  • Conclusions
  • (Acknowledgements)
  • References

Manuscripts should be prepared and submitted as MS Word files (download the word template here). The publication format will be PDF. The manuscript should be at least 1 page and should not exceed 9 pages (incl. figures, tables and references).

For publication of the Manuscript in Medical Sciences Forum, please carefully read the rules outlined in the 'Instructions for Authors' on the journal website and ensure that your manuscript submission adheres to these guidelines. The processing charges for publication in this journal depend on the length of the manuscript, 30 euros (1-4 pages) or 60 euros (5-9 pages). The papers will be published with a DOI, in a volume of the journal dedicated to the Meeting, using a CC BY 4.0 license meaning the authors retain copyright and the text can be reused.

Presentation Slides or Video

Authors are encouraged to prepare a collection of slides in PowerPoint or similar software or produce a Video, to be displayed online along with or alternatively to the manuscript. Authors that wish to present only the slides or the video, i.e., without a proceedings paper, can do it too.

Slides, if available, will be displayed directly in the website using the proprietary slides viewer at Sciforum.net. Slides can be prepared in the same way as for any traditional conference where research results are presented. Slides should be converted to PDF format before submission so that our process can easily and automatically convert them for online display. Videos should have a maximum size of 250 Mb and should be prepared in one of the following formats: mp4, webm or ogg.

Potential Conflict of Interest

It is the authors' responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there is no conflict, please state here "The authors declare no conflict of interest." This should be conveyed in a separate "Conflict of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Financial support for the study must be fully disclosed under "Acknowledgments" section.

Copyright

MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their scholarly works. Hence, by submitting a Conference paper to this conference, you retain the copyright of your paper, but you grant MDPI the non-exclusive right to publish this paper online on the Sciforum.net platform. This means you can easily submit your paper to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).

List of accepted submissions (12)

Id Title Authors Presentation Video
sciforum-061749

Use of lipid vesicles for revealing the potential contribution of cytochrome c in the metabolism of environmental toxicants

, , , N/A Show Abstract
sciforum-062121

Potential Applications of Vanadium-Based Anticancer Drugs for Intratumoral Injections


, , ,

Submitted: 16 May 2022

Abstract: Show Abstract
, , , N/A Show Abstract
sciforum-062418 The cytotoxicity of phorbol 12- myristate 13-acetate and lipopolysaccharide on THP-1 cells and optimized differentiation protocol , , N/A Show Abstract
sciforum-061613 Synthetic membranes as an alternative model to animal skin to investigate dermal permeation of chlorpyrifos

,

Submitted: 26 Apr 2022

Abstract: Show Abstract
, N/A Show Abstract
sciforum-063355 Targeting immune-mediated responses to tackle GNE myopathy

, ,

Submitted: 27 Jun 2022

Abstract: Show Abstract
, , N/A Show Abstract

Event Awards

One Best Contribution Award will be given to the submission judged to make the most significant contribution to the Meeting. To participate, a Full File (e.g. manuscript) of the work must be submitted to the event. The Award will consist of:

- A 500 Euro prize.
- A publication waiver at the Special Issue of the Meeting in the International Journal of Molecular Sciences.

Four Best Presentation Awards will be given to oral communications delivered in different Sessions. A 150 Euro prize will be awarded to the author presenting the work.

Two Best Poster Awards will be given to flash presentations in different Sessions. A 100 Euro prize will be awarded to the author presenting the work.

Sponsors and Partners

Organizers


Sponsors

* This event is managed by external organizers. Sciforum is not responsible for the content posted on this website.
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