Tuesday 06 September 2022

Rectorate of University of Florence, Piazza San Marco 4 50121 Florence

14:30 - 15:30

Registration check

15:30 - 15:45

Greetings from Prof. Debora Berti, Prorector for research, University of Florence

15:45 - 16:00

Welcome and chairing from Prof. Claudiu T. Supuran, chair of the conference

16:00 - 17:00

Keynote talk: Shoukat Dedhar, University of British Columbia, Canada
Targeting the Tumour Microenvironment

17:15 - 19:00

Welcome cocktail

Wednesday 07 September 2022

Centro Didattico Morgagni (CDM) - Morgagni Didactic Center
Via G.B. Morgagni 40, 50134 Florence

Session chaired by Dr. Clemente Capasso

09.00-10.00

Keynote talk: W. Alexander Donald, University of New South Wales, Australia
Multiplexed screening of thousands of natural products for protein binding in native mass spectrometry

10.00-10.30

Daniel Lietha - Structure and force activation of adhesion signalling

10:30 – 11:00 Coffee break

Session chaired by Dr. Clemente Capasso

11.00-11.30

Catherine Michaux - Revealing intrinsic disorder and aggregation properties of the DPF3 zinc finger proteins

11.30-12.00

Felix Nagel - Biophysical and Structural Insights into a Pancreatitis Associated Kazal Inhibitor

12.00-12.30

Mietha Van der Walt - Application of reverse pharmacophore mapping to search for protein targets of istradefylline – a drug repurposing perspective

12.30-13.00

Spyridon Gourdoupis - FEN1 as a target for confining oncogenesis

13.00-13.30

Filippo Favretto - Functional and Structural Characterization of two Cyclophilins from the parasite Toxoplasma gondii

13:30 – 15:00 Lunch time

Session chaired by Prof. Dr. Paola Gratteri and Prof. Dr. Claudiu T. Supuran

15.00-16.00

Keynote talk: Giuseppina De Simone, CNR Naples, Italy
Biochemical and structural studies on human carbonic anhydrase IX: a promising therapeutic target for cancer treatment

16.00-16.30

Anne Susemihl - BCL11B CCHC Zinc Finger Domain and Its Potential for Cancer Therapy

16.30-17.00

Aida Serra - Industry by-product EVs (BP-EVs) as a novel compound delivery platform for protein target within the Central Nervous System

17:00 – 17:30 Coffee break

17.30-18.00

Elena Krachmarova - Effect of SARS-CoV-2 ORF6 protein on DNA replication in eukaryotic cells

18.00-18.45

POSTER Session 1

Thursday 08 September 2022

Centro Didattico Morgagni (CDM) - Morgagni Didactic Center
Via G.B. Morgagni 40, 50134 Florence

Session chaired by Prof. Dr. Silvia Selleri and Dr. Clemente Capasso

09.00-10.00

Keynote talk: Binghe Wang, Georgia State University, USA
Examining the Therapeutic Effects of Carbon Monoxide: Seeing both the Forest and the Trees in Understanding Its Hemoprotein Targets

10.00-10.30

Jiri Cerven - Targetting Topoisomerase IIa: back to the drawing board via Z-DNA

10:30 – 11:00 Coffee break

11.00-12.00

Keynote talk: Marianna Patrauchan, Oklahoma State Univ., USA
Molecular pillars of calcium signaling in a bacterial pathogen: Pseudomonas aeruginosa.

12.00-12.30

Patrycja Gralewska - ATRi and CHK1i significantly increased chromosomal abnormalities caused by olaparib in HGSOC BRCAMUT and BRCAWT ovarian cancer cell lines

12.30-13.00

Katarzyna Walczewska-Szewc - How can interaction with prolyl oligopeptidase possibly trigger α-synuclein aggregation?

13.00-13.30

Marco Pedretti - Functional characterization of cystathionine gamma lyase from Pseudomonas aeruginosa

13:30 – 15:00 Lunch time

Session chaired by Prof. Dr. Giuseppina De Simone

15.00-16.00

Keynote talk: Jean-Yves Winum, University of Montpellier, France
Innovative approaches targeting carbonic anhydrases: an update

16.00-16.30

Gyula Batta - DMSO Induced Unfolding of the Antifungal Disulfide Protein PAF: a combined NMR and DSC study

16.30-17.00

Leandar Litov - Human interferon gamma is a potential inhibitor of SARS-Cov-2 Orf6 activity

17:00 – 17:30 Coffee break

Session chaired by Prof. Dr. Giuseppina De Simone

17.30-18.00

Massimiliano Gasparrini - Human extracellular NAMPT and NAPRT mediate inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction

18.00-18.45

POSTER Session 2

20:30

Social Dinner

Friday 09 September 2022

Centro Didattico Morgagni (CDM) - Morgagni Didactic Center
Via G.B. Morgagni 40, 50134 Florence

Session chaired by Prof. Dr. Jean-Yves WINUM

09.00-10.00

Keynote talk: Daniel P. Flaherty, Purdue University, USA
Bacterial carbonic anhydrase inhibitors for the treatment of drug resistant bacteria: A classical drug scaffold gets a new purpose.

10.00-10.15

Arianna Giacomini- Inhibition of Carbonic Anhydrase IX induces mitochondrial oxidative stress and apoptosis in multiple myeloma

10.15-10.45

Carsten Zeilinger - Strategies to display susceptibility of targets for compounds

10:45 – 11:15 Coffee break

Session chaired by Prof. Dr. Jean-Yves WINUM

11.15-12.15

Keynote talk: Lukasz Jaremko, King Abdullah University of Science and Technology, Saudi Arabia
Biological motions, gene regulation and drugs

12.15-12.45

Barbara Jachimska - Fibrinogen corona on the dendrimer nanoparticles

12.45-13.15

Olga Alekseeva - Variation in viral tropism belongs to IDPR positions in structural proteins of enterovirus

13:15 – 14:45 Lunch time

Session chaired by Prof. Dr. Claudiu T. Supuran, Prof. Dr. Paola Gratteri, Prof. Dr. Silvia Selleri and Dr. Clemente Capasso

14.45-15.45

Keynote talk: Vladimir Uversky, Univresity of South Florida, USA
Protein structure-function continuum: On the roles of intrinsic disorder in protein functionality

15.45-16.15 Ceremony awards and closing of the conference