*Note: Mol2Net conference is associated to different MDPI journals special issues guest edited by Mol2Net Conference Committee members. This is an strategy to increase the online post-publication visibility of papers and conference, promote post-publication brainstorming discussion, and increase authors feedback. This association implies that our conference perform post-publication indexing of selected papers already published in MDPI journals with the consent of the issue editors. We publish free-of-cost these post-publication summaries. They include a shortened title, corresponding author info, and paper cover pdf file. The cover pdf file contains paper first page with all authors, abstract, full reference , and link to original papers.

Reference: This is a post-publication summary note for the paper published in the special issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering, Edited by: Dr. I.A. Neacsu and Dr. B.S. Vasile, Managing Editor: C. Zha, Visit the link to see original paper. Reference: Pharmaceutics 2022, 14(9), 1962; https://doi.org/10.3390/pharmaceutics14091962

Biodegradability is one of the most important properties of implantable bone biomaterials, which is directly related to material bioactivity and the osteogenic effect. How foreign body giant cells (FBGC) involved in the biodegradation of bone biomaterials are regulated by the immune system is poorly understood. Hence, this study found that β-tricalcium phosphate (β-TCP) induced more FBGCs formation in the microenvironment (p = 0.0061) accompanied by more TNFα (p = 0.0014), IFNγ (p = 0.0024), and T-cells (p = 0.0029) than hydroxyapatite (HA), resulting in better biodegradability. The final use of T-cell depletion in mice confirmed that T-cell-mediated immune responses play a decisive role in the formation of FBGCs and promote bioceramic biodegradation. This study reveals the biological mechanism of in vivo biodegradation of implantable bone tissue engineering materials from the perspective of material-immune system interaction, which complements the mechanism of T-cells’ adaptive immunity in bone immune regulation and can be used as a theoretical basis for rational optimization of implantable material properties.

*Note: Mol2Net conference is associated to different MDPI journals special issues guest edited by Mol2Net Conference Committee members. This is an strategy to increase the online post-publication visibility of papers and conference, promote post-publication brainstorming discussion, and increase authors feedback. This association implies that our conference perform post-publication indexing of selected papers already published in MDPI journals with the consent of the issue editors. We publish free-of-cost these post-publication summaries. They include a shortened title, corresponding author info, and paper cover pdf file. The cover pdf file contains paper first page with all authors, abstract, full reference , and link to original papers.

Reference: This is a note for the paper published in the special issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering, Edited by: Dr. I.A. Neacsu and Dr. B.S. Vasile, Managing Editor: C. Zha, Visit the link to see original paper. Reference: Pharmaceutics 2022, 14(5), 941; https://doi.org/10.3390/pharmaceutics14050941

Summary:The incidence of type I diabetes has been increasing worldwide at an annual rate of approximately 3%. One of the strategies to treat type I diabetes is islet transplantation, in which damaged β-cells are replaced with new islets. To improve β-cells’ expansion and pseudoislet formation, studies are focusing on using extracellular-matrix-resembling substrates. We evaluated the potential of salmon fibrinogen and chitosan electrospun scaffold as cell substrate for cultivating MIN-6 cells. The morphology of cells, insulin secretion and gene expression was evaluated and compared with other substrates (nanofibrous scaffold, microporous scaffold and tissue culture polystyrene). We found that all tested 3D conditions favored the pseudoislet formation of MIN-6 cells. The insulin secretion of MIN-6 cells after stimulation with high-glucose media shows approximately a 9-fold increase compared to the control group when a fibrinogen/chitosan-based electrospun scaffold was used for cultivation. The differences in insulin secretion were corroborated by differences in gene expression. The differences in insulin secretion could probably be attributed to the differences in the mechanical and/or chemical nature of the tested substrates.

*Note: Mol2Net conference is associated to different MDPI journals special issues guest edited by Mol2Net Conference Committee members. This is an strategy to increase the online post-publication visibility of papers and conference, promote post-publication brainstorming discussion, and increase authors feedback. This association implies that our conference perform post-publication indexing of selected papers already published in MDPI journals with the consent of the issue editors. We publish free-of-cost these post-publication summaries. They include a shortened title, corresponding author info, and paper cover pdf file. The cover pdf file contains paper first page with all authors, abstract, full reference , and link to original papers.

Reference: This is a post-publication summary note for the paper published in the special issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering, Edited by: Dr. I.A. Neacsu and Dr. B.S. Vasile, Managing Editor: C. Zha, Visit the link to see original paper. Reference: Pharmaceutics 2022, 14(4), 858; https://doi.org/10.3390/pharmaceutics14040858

Summary: Specific targeting, selective stimuli-responsiveness, and controlled release of anticancer agents are requested for high therapeutic efficiency with a minimal adverse effect. Herein, we report the sophisticated synthesis and functionalization of fluorescent mesoporous silicon (FMPSi) nanoparticles decorated with graphene oxide (GO) nanosheets. GO-wrapped FMPSi (FMPSi@GO) was loaded with a cisplatin (Cis) anticancer agent, and Cis-loaded FMPSi@GO (FMPSi-Cis@GO) exhibited the dual stimuli (pH and NIR)-responsiveness of controlled drug release, i.e., the drug release rate was distinctly enhanced at acidic pH 5.5 than at neutral pH 7.0 and further enhanced under NIR irradiation at acidic pH condition. Notably, dequalinium-conjugated FMPSi-Cis@GO (FMPSi-Cis@GO@DQA) demonstrated an excellent specificity for mitochondrial targeting in cancer cells without noticeable toxicity to normal human cells. Our novel silicon nanocarriers demonstrated not only stimuli (pH and NIR)-responsive controlled drug release, but also selective accumulation in the mitochondria of cancer cells and destroying them.

In the real world, optimization problems have multiple objectives that usually are in conflict. Traditionally the Pareto-based approach has been applied to Multi-Objective Optimization Problems (MOPs). But this strategy has a limitation: The increment in the number of objectives produces issues. Such as the deterioration of the searchability of the algorithm. It reduces the selective pressure on the Pareto Front (PF). To address this problem, we propose an algorithm called MOSA/D. MOSA/D is a Multi-Objective Simulated Annealing (MOSA) strategy based on Decomposition (D) and Differential Evolution (DE). Decomposition divides a MOP into sub-problems that can be optimized almost in a classical sense, like single-optimization problems. With this idea, in MOSA/D, each sub-problem is annealed to find its optimal solution. During this annealing process, Differential Evolution produces candidate solutions to be evaluated by aggregation and probability functions. Simulated Annealing adds exploration and exploitation to each sub-problem while decomposition strategy and differential evolution operators reduce the lack of selective pressure toward the PF. MOSA/D is compared to MOEA/D to prove the performance of the algorithm. The experimental design used the DTLZ benchmark. In particular, the problems DTLZ1, DTLZ2, and DTLZ3 with five objectives. Experimental results show that MOSA/D outperforms or performs similarly to MOEA/D. These results are in terms of the mean and standard deviation from Hypervolume (HV) and Inverted Generational Distance (IGD).

*Note: Mol2Net conference is associated to different MDPI journals special issues guest edited by Mol2Net Conference Committee members. This is an strategy to increase the online post-publication visibility of papers and conference, promote post-publication brainstorming discussion, and increase authors feedback. This association implies that our conference perform post-publication indexing of selected papers already published in MDPI journals with the consent of the issue editors. We publish free-of-cost these post-publication summaries. They include a shortened title, corresponding author info, and paper cover pdf file. The cover pdf file contains paper first page with all authors, abstract, full reference , and link to original papers.

Reference: This is a summay for the paper published in the special issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering, Edited by: Dr. I.A. Neacsu and Dr. B.S. Vasile, Managing Editor: C. Zha, Visit the link to see original paper. Reference: Pharmaceutics 2022, 14(12), 2634; https://doi.org/10.3390/pharmaceutics14122634

Recently, research on and the application of nanomaterials such as graphene, carbon nanotubes, and metal–organic frameworks has become increasingly popular in tissue engineering. In 2014, a two-dimensional sheet of black phosphorus (BP) was isolated from massive BP crystals. Since then, BP has attracted significant attention as an emerging nanomaterial. BP possesses many advantages such as light responsiveness, electrical conductivity, degradability, and good biocompatibility. Thus, it has broad prospects in biomedical applications. Moreover, BP is composed of phosphorus, which is a key bone tissue component with good biocompatibility and osteogenic repair ability. Thereby, BP exhibits excellent advantages for application in bone tissue engineering. In this review, the structure and the physical and chemical properties of BP are described. In addition, the current applications of BP in bone tissue engineering are reviewed to aid the future research and application of BP.

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*Note: Mol2Net conference is associated to different MDPI journals special issues guest edited by Mol2Net Conference Committee members. This is an strategy to increase the online post-publication visibility of papers and conference, promote post-publication brainstorming discussion, and increase authors feedback. This association implies that our conference perform post-publication indexing of selected papers already published in MDPI journals with the consent of the issue editors. We publish free-of-cost these post-publication summaries. They include a shortened title, corresponding author info, and paper cover pdf file. The cover pdf file contains paper first page with all authors, abstract, full reference , and link to original papers.

Reference: This is a post-publication summary note for the paper published in the special issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering, Edited by: Dr. I.A. Neacsu and Dr. B.S. Vasile, Managing Editor: C. Zha, Visit the link to see original paper. Pharmaceutics 2022, 14(3), 510; https://doi.org/10.3390/pharmaceutics14030510

Lung cancer is the second-most common cancer and has the highest mortality among all cancer types. Nanoparticle (NP) drug delivery systems have been used to improve the therapeutic effectiveness of lung cancer, but rapid clearance and poor targeting limit their clinical utility. Here, we developed a nanomicelle-microsphere composite, in which doxorubicin (DOX) was loaded with spermine (Spm) modified poly (ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) micelles, and then the nanomicelles were noncovalently adsorbed on the surface of poly (lactic-co-glycolic acid) (PLGA) microspheres. The attachment was confirmed by scanning electron microscopy and confocal microscopy. In vitro cell experiments, MTT assays and intracellular uptake assays were used to demonstrate the cytotoxicity and the cellular uptake of micelles in A549 cells. In vivo biodistribution studies were conducted, an orthotopic lung cancer implantation model based on C57BL/6 mice was established, and then real-time fluorescence imaging analysis was used to study the targeted efficacy of the complex. A nanomicelle-microsphere composite was successively constructed. Moreover, Spm-modified micelles significantly enhanced cytotoxicity and displayed more efficient cellular uptake. Notably, an orthotopic lung cancer implantation model based on C57BL/6 mice was also successively established, and in vivo biodistribution studies confirmed that the complex greatly improved the distribution of DOX in the lungs and displayed notable tumor targeting. These results suggested that the nanomicelle-microsphere composite has potential application prospects in the targeted treatment of lung cancer.

In the last years, some Software Resources for Developing Multicriteria Applications (SRDMA) have been developed. The purpose of this review is to determine the state of the art on SRDMA to obtain a catalog of what has been developed which include libraries, frameworks, webservices and others. For this, it was performed a web search of research published in the last 10 years.

We have published this review in three different parts and presented the on three different congresses of Mol2Net series according to the topic. The publications and software found were classified into 3 different categories. Part 1: types of software resources developed (NIECXSM), Part 2: multicriteria methods implemented (USEDAT-08) and operating systems supported (CATCHTOHIT-03).

To analyze them we carry out a Contextual and a Formal Concept Analysis. Findings suggest that the type of software resources most developed was frameworks and the most used multicriteria methods were AHP and TOPSIS. The most supported operating systems were Windows, Linux and Mac. Thus, we consider that future research should contemplate the development of more generic SRDMA that implement a greater variety of multicriteria methods than those used up to now, which are available to developers through flexible licenses that allow them to be easily integrated into new application developments.

In the last years, some Software Resources for Developing Multicriteria Applications (SRDMA) have been developed. The purpose of this review is to determine the state of the art on SRDMA to obtain a catalog of what has been developed which include libraries, frameworks, webservices and others. For this, it was performed a web search of research published in the last 10 years.

We have published this review in three different parts and presented them on three different congresses of Mol2Net series according to the topic. The publications and software found were classified into 3 different categories. Part 1: types of software resources developed (NIECXSM), Part 2: multicriteria methods implemented (USEDAT-08) and operating systems supported (CATCHTOHIT-03).

To analyze them we carry out a Contextual and a Formal Concept Analysis. Findings suggest that the most supported operating systems were Windows, Linux and Mac. Thus, we consider that future research should contemplate the support of operating systems for mobile devices, which are widely used today.

In the last years, some Software Resources for Developing Multicriteria Applications (SRDMA) have been developed. The purpose of this review is to determine the state of the art on SRDMA to obtain a catalog of what has been developed which include libraries, frameworks, webservices and others. For this, it was performed a web search of research published in the last 10 years.

We have published this review in three different parts and presented them on three different congresses of Mol2Net series according to the topic. The publications and software found were classified into 3 different categories. Part 1: types of software resources developed (NIECXSM), Part 2: multicriteria methods implemented (USEDAT-08) and operating systems supported (CATCHTOHIT-03).

To analyze them we carry out a Contextual and a Formal Concept Analysis. Findings suggest that the most used multicriteria methods were AHP and TOPSIS. Thus, we consider that future research should contemplate the implementation of a greater variety of multicriteria methods than those used up to now.