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The 1st International E-Conference on Antioxidants in Health and Disease

Part of the International Online Conference on Antioxidants series
1–15 Dec 2020

Oxidative Stress, chronic disease, Disease Pathophysiology, Health Promotion, Dietary Antioxidants, Synthetic Antioxidants, Industrial Utilization
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We are delighted to announce that the 1st International e-Conference on Antioxidants in Health and Disease is now open for discussions from 1 to 15 December 2020.
We hope you enjoy the conference and make the most of it! We would like to take this opportunity to thank you for all your input and hope we can collectively make this conference a success!

See the full list of published papers at: https://cahd2020.sciforum.net/conference/CAHD2020/submissions/view

Invited Speakers

Freshage Research Group-Department of Physiology, Facultyof Medicine, University of Valencia, CIBERFES, INCLIVA, Spain

Introduction
Research Keywords
Interests: aging; stem cells; sex; frailty; cell culture; oxidative stress biomarkers; mitochondria; oxidative phosphorylation

Universita degli Studi di Roma La Sapienza, Department of Medico-Surgical Sciences and Biotechnologies, Roma, Italy

Introduction
Research Keywords
Interests: Oxidative stress; platelet function; cardiovascular disease; development of new markers of oxidative stress; nutraceutical in particular evaluation of antioxidant activities of natural products and food in patients and in healthy subjects

Institute of Mechanical, Process & Energy Engineering School of Engineering & Physical Sciences Heriot-Watt University Edinburgh, EH14 4AS United Kingdom

Introduction
Research Keywords
Interests: molecular dynamics simulation of protein-small molecule systems

Nutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, Spain.,
Dipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy,
College of Food Science and Technology, Northwest University, Xi’an, Shaanxi 710069, China

Introduction
Research Keywords
Interests: Nutrition; health; bioactive compounds; polyphenols; antioxidants; free radicals; oxidative stress; aging; mitochondrial functionality; apoptosis; strawberry; honey

Department of Biochemistry-Biotechnology , University of Thessaly, Larissa, Greece

Introduction
Research Keywords
Interests: redox biomarkers in blood, molecular evaluation of antioxidant profile of foods, functional food development

Department of Electron Microscopy & Molecular Pathology (EMMP), The Cyprus Institute of Neurology & Genetics (CING), 6 Iroon Avenue, Ayios Dometios, Nicosia, 2371, Cyprus

Introduction
Research Keywords
Interests: carcinogenesis; disease mechanisms; apoptosis; epigenetics; oxidative stress; natural products; experimental therapeutics; drug development; disease prevention; disease biomarkers

National Research Council, Institute of Food Sciences, Avellino, Italy

Introduction
Research Keywords
Interests: autophagy, apoptosis, cell cycle regulation, polyphenols, cancer biology

List of Keynotes & Videos from Invited Speakers

Keynotes

Genistein consumption does not increase lifespan, but it improves healthspan under stress conditions

by Consuelo Borras

Abstract

Genistein is a phytoestrogen which is extensively used in clinical practice, for instance to prevent menopause-associated hot flushes, as it can mimics some of the beneficial effects of estrogens and is devoid of significant side effects. It is present in soya in significant amounts and previous results of our group and others have shown that soya consumption can decrease oxidative stress and improve cardiovascular function in rats. In this study, we performed a controlled lifelong study with male OF1 mice consuming either a soya-free diet or a soya-rich diet. We found that, despite we found an increase in the expression and activity of antioxidant enzymes in soya consuming mice, it didn’t increase lifespan. We reasoned that soya diet was not able to increase lifespan in a very healthy population, but perhaps it could extend lifespan in stressed animals such as type 2 diabetic Goto Kakazaki rats. Indeed, this was the case, we found that rats consuming a soy rich diet developed the disease at a lower rate, showed lower oxidative stress and better metabolic profile, and therefore lived longer than soy-free diet consuming rats.

Keynotes

Modelling Polyphenol-Protein Interactions

by Stephen R. Euston

Abstract

The interaction between proteins and polyphenols is known to modify both the bioavailability and bioactivity of dietary polyphenols. Understanding these interactions can facilitate the design of delivery systems for polyphenols in the digestive tract. Molecular modelling of protein-polyphenol and protein-ligand interactions in general has long been used as a way to identify mall mole ule biding sites on proteins. However, these are often used without a careful consideration of the assumptions used and limitations of these methods, and how this affects the accuracy of the predictions. In this talk, two common methods for predicting binding site location and binding energy, molecular dynamics simulation and molecular docking, will be discussed. The simplifications and assumptions implicit in these approaches, as well as ways to improve their predictions will be covered.

Keynotes

Is the antioxidant capacity of flavonoids responsible for their anticancer effects? The case of quercetin in leukemia

by Gian Luigi Russo

Abstract

The concept that flavonoids, possessing well-known and characterized antioxidant capacity, can fight cancer is deeply rooted in the general population. On the opposite, a current of thought, argued by eminent scientists, attributes to free radical-destroying antioxidants the responsibility to negatively affect cancer incidence and therapy. The field is even more challenging considering that flavonoids possess both antioxidants and pro-oxidant activities and recent publications suggest that their beneficial anticancer effects can be easier explaining evoking the pro-oxidant capacity than the antioxidant one. In the present communication, we will analyze clinical and pre-clinical studies facing these sometimes paradoxical and contradictory concepts proposing that a clear distinction must be done between the use of flavonoids in cancer treatment versus cancer prevention, starting from adequate and specifically selected cellular and animal models. Among the multiple examples, the case of quercetin in chronic lymphocytic leukemia (CLL) will be considered. Quercetin, the most abundant flavonoid present in the diet, is able to modulate several hallmarks of cancer, including resistance to apoptosis. Our studies on this compound allowed us to decipher the biochemical pathway triggered by quercetin leading to demonstrate its capacity to synergistically sensitize several leukemia cell lines and B-cells isolated from CLL patients when associated with different classes of anticancer drugs. We also identified in the protein kinase CK2 the direct and primary target of quercetin, whose inhibition is correlated with the down-regulation of the PI3K/Akt signaling pathway and the massive apoptosis observed in CLL-derived cells. These data will be commented at the light of the very rapidly cellular uptake of quercetin and its capacity to lower intracellular concentrations of free radical species. Finally, considering the low toxicity of quercetin in normal peripheral blood cells, we will propose the design of clinical trials aimed to demonstrate its efficacy as a potential chemopreventive agent in the early phase of CLL.

Keynotes

The effects of strawberry bioactive compounds on lipid metabolism and adipogenesis

by Francesca Giampieri

Abstract

Obesity is one of the major problems of the 21st century worldwide. It is characterized by an expansion of white adipose tissue (WAT) mass resulting from increased adipocytes number and/or size. Excessive accumulation of mature adipocytes is associated with high lipid levels and with a general impairment of catabolic pathways. In this work, we evaluated the effect of a strawberry extract on lipid metabolism and adipogenesis on HepG2 cells and 3T3-L1 adipocytes. The results demonstrated that in HepG2 strawberry extract stimulated the LKB1/AMPK pathway leading to the inactivation of acetyl coenzyme A carboxylase (ACC) and inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the major regulators of fatty acids and cholesterol synthesis, respectively; it also stimulated LDL receptor, sirtuin 1 (Sirt1) and the peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α). In addition, strawberry extract reduced 3T3-L1 pre-adipocytes differentiation, lipid accumulation and down-regulated the mRNA expression of the adipogenic transcription factors CCAAT/enhancer-binding protein (C/REB-α) and peroxisome proliferation-activated receptor (PPAR-γ). Consistently, it inhibited the expression of fatty acid binding protein (FABP4), ACC and sterol regulatory element-binding protein (SREBP1), by activating AMPK pathway. Strawberry extract also inhibited oxidative stress and inflammation biomarkers, increased antioxidant enzymes activities and mitochondrial functionality. Our results suggest the potential anti-obesity effect of the bioactive components of strawberry.

Keynotes

The role of antioxidants supplementation in clinical practice: focus on cardiovascular risk factors

by Roberto Carnevale

Keynotes

Personalized Nutrition Plans based on Measurement of Specific Redox Biomarkers in Human Blood

by Dimitrios Koureta

Abstract

One of the most studied question in modern history is the particular way of bridging the gap between lifespan and healthspan? Even as average life expectancy has increased, there remains a sizeable gap between life span and health span — the years an individual lives without disease. The second question we must answer is the possibility that our lifespan and/or healthspan is “Programmed” in our genes? Or maybe there are other parameters that contribute to this model? Genome Analysis with “single nucleotide polymorphisms” (SNPs) of exceptionally long-lived people reveal 10-15% complex genetic signatures and very few genes consistently involved. The rest refers to the 3 pillars of metabolic health, the diet, the exercise, and the use of fasting in our everyday plan. Nutrient influence on healthy aging is being extensively studied in humans and in many animal models of aging. Moreover, the latest evidence is showing that regular physical activity can actually slow the aging process on a cellular level and potentially add years to your life. Additionally, intermittent fasting elicits evolutionarily conserved, adaptive cellular responses that are integrated between and within organs in a manner that improves glucose regulation, increases stress resistance, and suppresses inflammation. All these measurements proposed by our research team provides a holistic approach for the evaluation of redox status parameters for several conditions. Therefore, the effect of personalized nutrition on human redox status is evaluated and human health is improved.

Keynotes

Cruciferous Vegetables-Based Isothiocyanate Compounds as Novel Epigenetic Modulators in Human Malignant Melanoma

by Mihalis I. Panagiotidis

Abstract

Among the various types of dietary agents, isothiocyanates (ITCs) have raised the scientific interest with their unique properties, against disease development, including modulation of the epigenetic machinery. In the context of malignant melanoma, our research efforts have aimed to understand how ITCs induce cell death by interacting with the epigenetic machinery and thus leading to inhibition of tumor growth. For this purpose, we have utilized an experimental in vitro model of human malignant melanoma consisting of normal keratinocytes, primary and metastatic melanoma as well as non-melanoma epidermoid carcinoma cell lines. In this model, specific ITCs [e.g. sulforaphane (SFN), iberin (IBN) and allyl isothiocyanate (AITC)] were examined for their ability to influence histone acetylation and methylation marks, as a potential epigenetic therapeutic strategy against melanoma. Overall, we report that all ITCs inhibited melanoma cell proliferation and influenced acetylation and methylation status of specific lysine residues on H3 and H4 by modulating the expression of various histone acetyl transferases (HATs), histone deacetylases (HDACs) and histone methyl transferases (HMTs), in malignant melanoma cells. Our data highlight novel insights on SFN, IBN and AITC interaction with components of the histone regulatory machinery, to exert their anticancer action in malignant melanoma.

List of accepted submissions (44)

Id Title Authors Presentation Video Poster PDF
sciforum-034013 Brenania Brieyi root bark extracts ameliorate chronic inflammation-mediated oxidative stress in Wistar rats , , , N/A Poster PDF Show Abstract
sciforum-035094 Redox behavior of central-acting opioid Tramadol and its possible role in oxidative stress

, ,

Submitted: 18 Sep 2020

Abstract: Show Abstract
, , N/A Poster PDF Show Abstract
sciforum-035598 Physical-chemical properties of the phenolic compounds of Humulus lupulus and aromatic plant terpenes; potential for use in a cosmetic formulation , , , N/A N/A Show Abstract
sciforum-036325 Influence of organic and conventional agricultural practices on chemical profile, in vitro antioxidant and anti-obesity properties of Zingiber officinale Roscoe , , , , , N/A Poster PDF Show Abstract
sciforum-036329 Extracts of different polarity of Daphne laureola L. as valuable source of antioxidant and neuroprotective compounds

, , , ,

Submitted: 04 Oct 2020

Abstract: Show Abstract
, , , , N/A N/A Show Abstract

Conference Chairs

Department of Electron Microscopy & Molecular Pathology (EMMP), The Cyprus Institute of Neurology & Genetics (CING), 6 Iroon Avenue, Ayios Dometios, Nicosia, 2371, Cyprus

Introduction
Bio
will be updated soon.

Conference Committee

Editorial Board Member of Antioxidants

Introduction
Research Keywords
Interests: clinical nutrition; clinical trials research; dietary antioxidants; vitamin E; vitamin C; carotenoids; omega-3 fatty acids; women's health

Freshage Research Group-Department of Physiology, Facultyof Medicine, University of Valencia, CIBERFES, INCLIVA, Spain

Introduction
Research Keywords
Interests: aging; stem cells; sex; frailty; cell culture; oxidative stress biomarkers; mitochondria; oxidative phosphorylation

Universita degli Studi di Roma La Sapienza, Department of Medico-Surgical Sciences and Biotechnologies, Roma, Italy

Introduction
Research Keywords
Interests: Oxidative stress; platelet function; cardiovascular disease; development of new markers of oxidative stress; nutraceutical in particular evaluation of antioxidant activities of natural products and food in patients and in healthy subjects

Democritus University of Thrace, Komotini, Greece

Institute of Mechanical, Process & Energy Engineering School of Engineering & Physical Sciences Heriot-Watt University Edinburgh, EH14 4AS United Kingdom

Introduction
Research Keywords
Interests: molecular dynamics simulation of protein-small molecule systems

Nutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, Spain,
Dipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy,
College of Food Science and Technology, Northwest University, Xi’an, Shaanxi 710069, China

Introduction
Research Keywords
Interests: Nutrition; health; bioactive compounds; polyphenols; antioxidants; free radicals; oxidative stress; aging; mitochondrial functionality; apoptosis; strawberry; honey

Department of Biochemistry-Biotechnology , University of Thessaly, Larissa, Greece

Introduction
Research Keywords
Interests: redox biomarkers in blood, molecular evaluation of antioxidant profile of foods, functional food development

Department of Chemical Sciences, University of Naples ‘Federico II’, Naples, Italy

Introduction
Research Keywords
Interests: structure and properties of melanins; chemistry of melanogenesis; oxidation chemistry of natural polyphenols of both dietary and metabolic origin and their coupling reactions with biological thiols et al.

CHU-University of Liège, Department of Cardiovascular Surgery/Antioxidant Nutrition and Health Platform, Sart Tilman, 4000 Liège, Belgium

Introduction
Research Keywords
Interests: biomarkers of in vivo oxidative stress; polyphenols (food and extracts characterization, blood analysis); in vitro and in vivo endothelium function; clinical studies (cardiovascular, dialysis, COPD, muscular dystrophy, ...)

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain,
CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain

Introduction
Research Keywords
Interests: Phenolic compounds, obesity, insulin resistance, liver steatosis

University of Thessaly, Department of Biochemistry and Biotechnology, Larissa, Greece

Introduction
Research Keywords
Interests: Antioxidant activity of plant extracts, plant polyphenols and other natural products; Physiological adaptive mechanisms of human organism to oxidative stress conditions; Chemopreventive activity of natural compounds.

Hospital General de Requena, Valencia, Spain

Introduction
Research Keywords
Interests: antioxidants, oxidative and nitrosative stress, retinal diseases, nervous tissue

National Research Council, Institute of Food Sciences, Avellino, Italy

Introduction
Research Keywords
Interests: autophagy, apoptosis, cell cycle regulation, polyphenols, cancer biology

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain,
CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain

Introduction
Research Keywords
Interests: Phenolic compounds, obesity, insulin resistance, liver steatosis

Welcome from the Chair

Dear Colleagues,

You are cordially invited to participate in the 1st International e-Conference on Antioxidants in Health and Disease. This event will bring together researchers working in the field of antioxidants to present and discuss their latest research findings.

The field of antioxidants is continually expanding, as many of them have been shown to exert a preventive and/or therapeutic effect on disease development. However, their underlying mechanism of action is still, largely, unexplored and consequently not well understood. This conference will address a variety of research topics, which will be organized into the following four sessions:

Dietary Antioxidants and Health Promotion: From Epidemiology to Policy Making

Antioxidants in Chronic Disease: From Dietary Prevention to Therapeutic Intervention

The Biology of Natural Products in Disease Pathophysiology: Mechanisms of Action

Synthetic Antioxidants for Industrial Utilization: From Novel Structures to Innovative Applications

The conference is organized by the MDPI open access journal Antioxidants (Impact Factor 5.014). Accepted abstracts will be published in the proceedings of the conference, and authors will be invited to submit their abstracts as full manuscripts that will be considered for publication in a Special Issue of Antioxidants, with a 20% discount on the APC.

We hope you will choose to be a part of this exciting conference and look forward to welcoming you.

CAHD 2020 Conference Chair

Prof. Dr. Mihalis I. Panagiotidis

Conference Secretariat

Ms. Edith Fang
Ms. Betsy Feng

Instructions for Authors

Instruction for Authors

Submission

Submission should be completed online by authors by registering with https://sciforum.net/ and using the “Start New Submission” function once logged into system (no registration fees).

  1. Scholars interested in participating in the conference can submit their abstract (about 200–300 words describing the manuscript for Proceedings) online at this website until 30 September 2020.
  2. Based on the submitted abstract, the Conference Committee will conduct a pre-evaluation of whether a contribution from the authors of the abstract will be welcome for the 1st International Electronic Conference on Antioxidant Science. All authors will be notified by 10 October 2020 about the acceptance of their abstract.
  3. If the abstract is accepted for this conference, the author will be invited to prepare a full description of their work (max. 8 pages), optionally accompanied by a PowerPoint presentation/poster, until the submission deadline of 10 November 2020.
  4. The conference proceedings papers and presentations will be available for discussion on https://sciforum.net/conference/CAHD2020 during the time of the conference 1–15 December 2020 and will be published in the journal Proceedings.
  5. The open access journal Antioxidants will publish a conference Special Issue, while accepted abstracts will be published in the conference proceedings. After the conference, the Conference Committee will select abstracts for which extended papers may be included for publication in the Special Issue of the journal Antioxidants (the submission to the journal is independent from the conference proceedings and will follow the usual process of the journal, including peer review and application of an APC).

Proceedings Manuscripts

Manuscripts for Proceedings must conform to the following structure:

First page:

  • Title
  • Full author names
  • Affiliations (including full postal address) and authors’ email addresses
  • Abstract (200–250 words)
  • Keywords
  • Introduction
  • Methods
  • Results and Discussion
  • Conclusions
  • (Acknowledgments)
  • References

Manuscripts should be prepared in MS Word or any other word processor and should be converted to PDF format before submission. The publication format will be PDF. The manuscript should count at least 3 pages (incl. figures, tables, and references) and should not exceed 8 pages.

Microsoft Word

Authors must use the Microsoft Word template to prepare their manuscript. Using the template file will substantially shorten the time to complete copy-editing and publication of accepted manuscripts. Manuscript prepared in MS Word must be converted into a single file before submission. Please do not insert any graphics (schemes, figures, etc.) into a movable frame which can superimpose the text and create difficulties related to layout.

CAHD2020-template.docx

Manuscript Preparation

  • Paper Format: A4 paper format, the printing area is 17.5 cm × 26.2 cm. The margins should be 1.75 cm on each side of the paper (top, bottom, and left and right sides).
  • Formatting/Style: Papers should be prepared following the style of the Plants 2020 template. The full titles and cited papers must be given. Reference numbers should be placed in square brackets [ ], and placed before the punctuation; for example, [4] or [1–3], and all the references should be listed separately as the last section at the end of the manuscript.
  • Author List and Affiliation Format: Authors’ full first and last names must be given. Any abbreviated middle names can be added. For papers written by various contributors, a corresponding author must be designated. The PubMed/MEDLINE format is used for affiliations: complete street address information including city, zip code, state/province, country, and email address should be added. All authors who contributed significantly to the manuscript (including writing a section) should be listed on the first page of the manuscript, below the title of the article. Other parties, who provided only minor contributions, should only be listed under Acknowledgments. A minor contribution might be a discussion with the author, reading through the draft of the manuscript, or performing English corrections.
  • Figures, Schemes, and Tables: Authors are encouraged to prepare figures and schemes in color. Full color graphics will be published free of charge. Figure and schemes must be numbered (Figure 1, Scheme I, Figure 2, Scheme II, etc.) and an explanatory title must be added. Tables should be inserted into the main text with numbers and titles supplied for all tables. All table columns should have an explanatory heading. Please supply legends for all figures, schemes, and tables. The legends should be prepared as a separate paragraph of the main text and placed in the main text before a table, figure, or scheme.

Presentation Slides

Authors are encouraged to prepare a presentation in PowerPoint or similar software, to be displayed online along with the manuscript. Slides, if available, will be directly displayed on the website using Sciforum.net’s proprietary slides viewer. Slides can be prepared in exactly the same way as for any traditional conference where research results can be presented. Slides should be converted to the PDF format before submission so that our process can easily and automatically convert them for online displaying.

CAHD2020-PPT-template.pptx

Video Presentations

Authors are also encouraged to submit video presentations. The video should be no longer than 20 minutes and be prepared with the following formats:

  • MOV
  • MPEG4
  • MP4
  • AVI
  • WMV
  • MPEGPS
  • FLV

The video should be submitted via email before 10 November 2020.

Presentation of Posters

Posters will be available on this conference website during and after the event. As with papers presented at conferences, participants will be able to ask questions and make comments about the posters. Posters can be presented without an accompanying Proceedings paper will be available online on this website during and after the e-conference. However, they will not be added to the proceedings of the conference.

Potential Conflicts of Interest

It is the authors’ responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there are no conflicts, please state here “The authors declare no conflicts of interest”. This should be conveyed in a separate “Conflicts of Interest” statement preceding the “Acknowledgments” and “References” sections at the end of the manuscript. Financial support for the study must be fully disclosed under the “Acknowledgments” section.

Copyright

MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their scholarly works. Hence, by submitting a communications paper to this conference, you retain the copyright of your paper, but you grant MDPI the non-exclusive right to publish this paper online on the Sciforum.net platform. This means you can easily submit your paper to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).

Sponsors and Partners

Organizers

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