Synthesis of Some 2,6-Disubstituted 4-Pyridinecarboxamides and -Carbothioamides, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Miroslav Miletin; Jiri Hartl; Martin Dolezal; Zelmira Odlerova; Katarina Kralova; Milos Machacek

doi:10.3390/ecsoc-2-01695

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Synthesis of Some 2,6-Disubstituted 4-Pyridinecarboxamides and -Carbothioamides, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Miroslav Miletin

^{*

1},

Jiri Hartl

¹,

Martin Dolezal

¹,

Zelmira Odlerova

²,

Katarina Kralova

³,

Milos Machacek

⁴

¹ Department of Medicinal Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
² Institute of Preventive and Clinic Medicine, Bratislava, Slovak Republic
³ Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
⁴ Department of Inorganic and Organic chemistry, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01695

Abstract: A group of 26 new 6-halogeno- or 6-alkylsulfanyl-2-alkylsulfanylpyridine-4-carboxamides and corresponding carbothioamides was synthesised. Some of the amides and all thioamides were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amides.

Keywords: Pyridininecarbothioamides, antimycobacterial activity, photosynthesis-inhibiting activity.

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