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Multi-target Design, Synthesis and Study of a Selected Series of Carbamates and Esters with Coumarin Scaffold
* 1, 2 , 1, 2 , 1 , 3 , 1 , 2 , 2
1  CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007Porto, Portugal
2  Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain
3  Dipartimento di Farmacologia, Facoltà di Farmacia, Università di Catanzaro, Italy

Abstract: Developed countries\' society face, with the increase of the population life expectancy, a major problem related with neurodegenerative diseases (ND), such as Parkinson\'s and Alzheimer\'s diseases. Therefore, a need for new drugs targeting these diseases emerges. Some of the few accessible treatments use monoamine oxidases inhibitors (MAOI-A and MAOI-B) and acetylcholinesterase inhibitors (AChEI). Coumarins are a large family of compounds of natural and/or synthetic origin that proved to have numerous pharmacological properties. In this study, we developed new synthetic methodologies to create novel multi-target inhibitors focused on the coumarin scaffold. Following this work, docking studies of the previously prepared compounds are currently in progress. Some preliminary results are presented in this communication.
Keywords: Coumarins; carbamate and esters derivatives; neurodegenerative diseases; MAO inhibition; AChEI inhibition; docking studies