Previous Article in event Previous Article in session
Next Article in event
Synthesis of Bioactive Sulfonamides Bearing Piperidine Nucleus with Talented Activity Against CholinesteraseNext Article in session
Synthesis and Chemical Reactivity of the Novel 6,8-Dibromo-7-hydroxychromone-3-carboxaldehyde
Published: 26 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A novel 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde (4) was prepared from the Vilsemier-Haack formylation of 3,5-dibromo-2,4-dihydroxyacetophenone. The chemical reactivity of carboxaldehyde 4 was studied towards some hydrazine derivatives under different reaction conditions. 1,3,4-Thiadiazol-2-ylchromone derivative 10 was also prepared. The chemical behavior of carboxaldehyde 4 was studied towards hydroxylmine hydrochloride under different reaction conditions to produce compounds 11-14. The reaction mechanism and mass spectrometry for some compounds were also reported.
Keywords: chromone-3-carboxaldehyde, nucleophilic reactions, ring opening ring closure reactions, mass spectrometry.