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Synthesis and Chemical Reactivity of the Novel 6,8-Dibromo-7-hydroxychromone-3-carboxaldehyde
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1  Department of Chemsity, Faculty of Education, Ain Shams University

Abstract: A novel 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde (4) was prepared from the Vilsemier-Haack formylation of 3,5-dibromo-2,4-dihydroxyacetophenone. The chemical reactivity of carboxaldehyde 4 was studied towards some hydrazine derivatives under different reaction conditions. 1,3,4-Thiadiazol-2-ylchromone derivative 10 was also prepared. The chemical behavior of carboxaldehyde 4 was studied towards hydroxylmine hydrochloride under different reaction conditions to produce compounds 11-14. The reaction mechanism and mass spectrometry for some compounds were also reported.
Keywords: chromone-3-carboxaldehyde, nucleophilic reactions, ring opening ring closure reactions, mass spectrometry.