Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins

Houssein Ibrahim; Giang Vo-Thanh

doi:10.3390/ecsoc-16-01070

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Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins

Houssein Ibrahim

Giang Vo-Thanh

¹ University Paris-Sud 11

Published: 29 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-16-01070

Abstract: A new class of monophosphine ligands has been prepared from naturally chirality renewable source, 1,4 :3,6-dianhydrohexitol compounds, via a nucleophilic substitution process or a hydrophosphination reaction involving microwave activation. These ligands have been evaluated for the rhodium-catalyzed enantioselective hydrogenation of olefins giving good conversion and enantioselectivity up to 95% and 96% ee, respectively.

Keywords: Monophosphine ligands, Isosorbide, Isomannide, Hydrogenation

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Houssein Ibrahim

Giang Vo-Thanh