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Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins
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1  University Paris-Sud 11

Abstract: A new class of monophosphine ligands has been prepared from naturally chirality renewable source, 1,4 :3,6-dianhydrohexitol compounds, via a nucleophilic substitution process or a hydrophosphination reaction involving microwave activation. These ligands have been evaluated for the rhodium-catalyzed enantioselective hydrogenation of olefins giving good conversion and enantioselectivity up to 95% and 96% ee, respectively.
Keywords: Monophosphine ligands, Isosorbide, Isomannide, Hydrogenation