Zr-Catalyzed Cycloalumination of 1,2-Dienes in the Synthesis of Lyngbioic Acid Derivatives.

Elina Makarova; Alexey Makarov; Lilya Dzhemileva; Usein Dzhemilev

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Ti-catalyzed cross-cyclomagnesiation in the synthesis of natural and synthetic dienoic and trienoic fatty acids exhibiting a wide range of biological activities.

Zr-Catalyzed Cycloalumination of 1,2-Dienes in the Synthesis of Lyngbioic Acid Derivatives.

Elina Makarova

^*,

Alexey Makarov

^*,

Lilya Dzhemileva

^*,

Usein Dzhemilev

¹ IPC RAS

Academic Editor: Kotohiro Nomura

Published: 14 October 2021 by MDPI in The 2nd International Electronic Conference on Catalysis Sciences—A Celebration of Catalysts 10th Anniversary session Catalysis in Organic and Polymer Chemistry

https://doi.org/10.3390/ECCS2021-11038 (registering DOI)

Abstract:

Using at the key stage of the synthesis the reaction of catalytic cycloalumination of 1,2-dienes with Et3Al in the presence of catalytic amounts of Cp2ZrCl2 (Dzhemilev reaction), an original method for the preparation of analogs of natural Lyngbioic acid with high yields and stereoselectivity was developed, which are key synthons in the preparation of derivatives natural Grenadamide.

Keywords: Zr-Catalyzed Cycloalumination, analogs of natural Lyngbioic acid.

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Elina Makarova

Alexey Makarov

Lilya Dzhemileva

Usein Dzhemilev