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Bora Rice: Natural polymer for drug delivery
* 1 , 1 , 1 , 1 , 2
1  Department of Pharmaceutical Sciences,Dibrugarh University
2  Department of Pharmaceutics,college of Pharmacy,Najran University,Kingdom of Saudi Arabia
Academic Editor: Marina Arrieta


Natural polymers play a vital part in the formulation of pharmaceutical dosage forms because of their use as excipients. Synthetic polymers have been introduced into drug delivery recently, the usage of natural polymers in drug delivery research continues to rise. It is not surprising that applications other than its caloric value have been found for starch. Various natural source of the polymer has been focused for delivery systems among them Assam bora rice starch seems to be a better candidate because of interesting properties such as non-toxic, biocompatible, biodegradable, mucoadhesive and non-immunogenic properties. Assam Bora rice, locally known as Bora Chaul, was first introduced in Assam, India, from Thailand or Myanmar by Thai-Ahom, now widely cultivated throughout the Assam. The starch obtained from Assam Bora rice is characterized by its high amylopectin content (i.e., > 95%) with a branched waxy polymer which shows physical stability and resistance towards enzymatic action. Assam Bora rice starch hydrates and swells in cold water, forming viscous colloidal dispersion or sols responsible for its bioadhesive nature. Moreover, it is degraded by colonic bacteria but remains undigested in the upper GIT. Due to the excellent adhesion and gelling capability, it is often selected as a mucoadhesive matrix in a controlled release drug delivery system. Carboxymethyl Assam Bora rice starch has also been applied for SPIONs stabilization and further it's ability to effectively bind and load cationic anti-cancer drug molecule, Doxorubicin hydrochloride (DOX), via electrostatic interaction.This article provides a critical assessment of Assam bora rice literature and shows how the rice can be used in many ways, from food additives to drug delivery systems.

Keywords: Assam Bora rice, Starch, Natural polymer, Mucoadhesive agent, Drug delivery system