The aim of this review was to summarize any evidence-based clinical uses of thalassotherapy. PubMed was searched up to the 15th July 2021 for relevant studies. Overall, 560 articles were found and 14 studies were included in this review. Clinical efficacy of thalassotherapy was mostly tested for skin problems (psoriasis, atopic dermatitis, vitiligo) and rheumatic disorders (fibromyalgia, ankylosing spondylitis). Disease severity and the patients’ quality of life significantly improved after intervention, with the majority of evidence for psoriasis and fibromyalgia. Thalassotherapy can be associated with symptomatic improvements in some health conditions. Further studies on the topic are recommended.