This study investigates the influences of natural and human-induced spatial blocking on the morphological and hydrodynamic features of the Tien Chau tidal inlet. It is observed that the absence of the downdrift barrier island and the appearance of the headlands form a squeeze tidal inlet. Moreover, anthropogenic factors, including urbanization and aquacultures, block a large part of the flood-tidal delta. These natural and human-induced spatial restrictions have significant influences on the hydro and morphodynamic characteristics of the inlet. In order to obtain more insight, a schematized numerical model was constructed in the Delft3D model and validated using measured field data.