Covalent binding of C60 fullerene to quadricyclans: a synthetic avenue to hexamethanofullerenes with promising antitumor activity

¹ 450075 Institute of petrochemistry and catalysis of RAS Pr. Oktyabrya 141, Ufa, Russia
² 450075 Institute of petrochemistry and catalysis of RAS Pr. Oktyabrya 141, Ufa, Russia

Academic Editor: Julio A. Seijas

Published: 13 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-25-11649

Abstract:

Using the Bingel-Hirsch reaction, two new hexamethanofullerenes containing six quadricyclane fragments have been synthesized. Preliminary experiments have established that the synthesized compounds have a high antitumor effect in combination with cis-platinum on human T-lymphoblastic leukemia cells (Jurkat cells).

Keywords: [60]fullerene; quadricyclane; Bingel-Hirsh reaction; hexamethanofullerene; cytotoxic; antitumor activity

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