The search for structures that fold in the form of peptide turns, in which α-amino acids are totally or partially replaced by constraints made up of β- or γ-amino acids is of great interest. But so are those structures in which α-amino acids are amino acids are replaced by non-amino acid molecules, which also give rise to peptide turns. The interest, in both cases, is due to the limitations of the α-peptides, mainly its low structural diversity, due to the limited number of proteinogenic acids as well as its remarkable conformational flexibility and low metabolic stability.

This communication deals with the turn inducer properties of peptidomimetic I. Its synthesis and structural study will be discussed.