For polar Diels-Alder (DA) reactions one of the most relevant aspects is its dependence on the reaction media so in this work the objective is to analyze the effect of aqueous micellar systems on the synthesis of compounds of biological interest. Based on the system formed by isoprene and 2-nitrofuran, the experiments were carried out in micellar media formed by amphiphilic ionic liquids (N,N-dodecylmethylimidazolium bromide) and by conventional surfactants (SDS and CTAB).

In this sense, there are few studies that involve DA reactions in micro-heterogeneous systems.

The challenge is to have the knowledge about the behavior of ILs in order to take advantage of all their potentialities in order to replace a toxic molecular solvent with ILs that allows developing a methodology framed within the concepts of Green Chemistry.