We have reported herein a simple and efficient synthesis method of thymyl ethers for structural modifications of natural products such as monoterpenoids and studies of ether derivatives of thymol in biological importance.The investigations showed that thymol reacts very smoothly with different types of substituted acetanilides.The synthesized compounds have been tested for their bacterial potency against four bacterial species. Such a structural modification will be beneficial in the field of pest management for designing the active molecules.