A series of ten 1,5-disubstituted-1H-tetrazoles (1,5-DS-T) were synthesized via isocyanide-based multicomponent reactions (IMCR) Ugi-azide in low to excellent yields, using propargyl amine or 2-azidobenzaldehyde as component under ultrasound irradiation (USI). 1,5-DS-T are useful heterocyclic moieties present in many bioactive compounds and drugs. Morever 1,5-DS-T are used as bidentate ligands, in coordination chemistry, metal-organic framework science, bioimaging, photo-imaging, explosives, propellants, high energy materials. The generated products can be used as synthetic platforms for subsequent post-transformations.