(1) Background: Osteonecrosis is a rare disease, characterized by the death of bone components and that has as a primary characteristic the considerable reduction in the quality of life of the affected patient, usually young adults. In this context, the purpose of this study is a literature review to evaluate natural products as adjuvants in the treatment of osteonecrosis, their efficacy and main results;

(2) Methods: A search was made in three bibliographic platforms, and the works that addressed the efficacy of natural products as adjuvants in the treatment of osteonecrosis were selected;

(3) Results: Three main natural products showed results of great impact, ratifying the need for further studies on the subject;

(4) Conclusion: The use of natural products presented itself as a promising alternative to be employed as adjuvant to the treatment of osteonecrosis. Therefore, the need for further studies is identified, with the purpose of other natural products that play similar and/or superior roles to those currently known regarding the treatment of osteonecrosis and its adjuvants.