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Synthesis of new highly functionalized nicotinic acids
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Academic Editor: Julio A. Seijas
Published:
14 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
https://doi.org/10.3390/ecsoc-25-11800
(registering DOI)
Abstract:
2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with cyanoacetic acid hydrazide in the presence of KOH to give 1-amino-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylic acid, which is useful as drug precursors or perspective ligands.
Keywords: enamino-1,3-dicarbonyls, cyanoacethydrazide, nicotinic acid
