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Unique protein expression profiles discriminate ex vivo differentiated monocytic MDSCs from TAMs.
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Academic Editor: Humbert G. Díaz
Published:
23 March 2022
by MDPI
in MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed.
congress NICE.XSM-08: North-Ibero-America Congress on Exp. & Simul. Methods, Valencia, Spain-Miami, USA, 2022
Abstract:
Detailed knowledge of tumor biology is necessary for tumor reprogramming. Tumor associated macrophages (TAMs) and monocytic myeloid suppressor cells (m-MDSCs) are major tumor-promoting cells within the tumor microenvironment (TME). Differentiation of m-MDSC and TAMs is shaped by tumor microenvironment. Several factors have been shown to drive m-MDSC differentiation into TAMs, indicating that they are two different populations. However, TAMs and m-MDSC closely related functions, phenotypic similarities and differentiation plasticity contributes to the confusion over their ontogeny and differential characteristics. Here, we revealed the key differences between m-MDSC and TAMs, focused on differential pathways by high-throughput proteomics.
Keywords: monocytic myeloid supressor cells (m-MDSCs), Tumor associated macrophages (TAMs) ,tumor microenvironment (TME).
Comments on this paper
Humbert G. Díaz
1 January 2023
Dear authors thank you for your support to the conference.
Now we closed the publication phase and launched the post-publication phase of the conference.
REVIEWWWERS'08 Brainstorming Workshop is Now Open from 2023-Jan-01 to 2023-Jan-31.
MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide ...
Invited to Post Moderated Questions/Answers, Comments, about papers.
These are my Questions (Q) to you, please kindly post your public Answers (A) below
to promote scientific discussion and training of conference readers :
Q1. What are the basis of the Tfacts algorithm? It is the same than in the following reference:
Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J, Demoulin JB: Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data. Nucleic Acids Res. 2010, 38 (11): e120-10.1093/nar/gkq149.
Q2. Have you considered to compare the results of the following algorithms, TFact, RIF, CSA, and DRrank,
with your data, according to: BMC Bioinformatics volume 15, Article number: P33 (2014)
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-15-S10-P33
Thank you for your kind support. Please make questions to other papers in different Mol2Net congresses
Login, Go to [MOL2NET'22 Papers List], Select Paper, Comment, Validate email...
See link: https://mol2net-08.sciforum.net/#reviewwwers
Now we closed the publication phase and launched the post-publication phase of the conference.
REVIEWWWERS'08 Brainstorming Workshop is Now Open from 2023-Jan-01 to 2023-Jan-31.
MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide ...
Invited to Post Moderated Questions/Answers, Comments, about papers.
These are my Questions (Q) to you, please kindly post your public Answers (A) below
to promote scientific discussion and training of conference readers :
Q1. What are the basis of the Tfacts algorithm? It is the same than in the following reference:
Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J, Demoulin JB: Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data. Nucleic Acids Res. 2010, 38 (11): e120-10.1093/nar/gkq149.
Q2. Have you considered to compare the results of the following algorithms, TFact, RIF, CSA, and DRrank,
with your data, according to: BMC Bioinformatics volume 15, Article number: P33 (2014)
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-15-S10-P33
Thank you for your kind support. Please make questions to other papers in different Mol2Net congresses
Login, Go to [MOL2NET'22 Papers List], Select Paper, Comment, Validate email...
See link: https://mol2net-08.sciforum.net/#reviewwwers
Iratxe Aguado
3 January 2023
Dear authors thank you for your support to the conference.
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS'08 Brainstorming Workshop is now open from 2023-Jan-01 to 2023-Jan-31. MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide are invited to post moderated questions/answers, comments, about papers. Please kindly post your public answers (A) to the following questions in order to promote interchange of scientific ideas. These are my questions (Q) to you:
Q1. Can this be extrapolated to any kind of tumour?
Q2. Could there, one day, be an application of these results in the form of a diagnostic kit?
Dear author thanks in advance for your kind support answering the questions. Now, please become a verified REVIEWWWER of our conference by making questions to other papers in different Mol2Net congresses. Commenting Steps: Login, Go to Papers List, Select Paper, Write Comment, Click Post Comment. Papers list: https://mol2net-08.sciforum.net/presentations/view,
Workshop link: https://mol2net-08.sciforum.net/#reviewwwers
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS'08 Brainstorming Workshop is now open from 2023-Jan-01 to 2023-Jan-31. MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide are invited to post moderated questions/answers, comments, about papers. Please kindly post your public answers (A) to the following questions in order to promote interchange of scientific ideas. These are my questions (Q) to you:
Q1. Can this be extrapolated to any kind of tumour?
Q2. Could there, one day, be an application of these results in the form of a diagnostic kit?
Dear author thanks in advance for your kind support answering the questions. Now, please become a verified REVIEWWWER of our conference by making questions to other papers in different Mol2Net congresses. Commenting Steps: Login, Go to Papers List, Select Paper, Write Comment, Click Post Comment. Papers list: https://mol2net-08.sciforum.net/presentations/view,
Workshop link: https://mol2net-08.sciforum.net/#reviewwwers
