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Ameliorative effect of curcumin and soya extract against arsenic toxicity in Drosophila melanogaster
Published:
27 May 2022
by MDPI
in MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed.
congress BIOMODE.ECO-07: Biotech., Mol. Eng., Nat. Products Develop. and Ecology Congress, Paris, France-Ohio, USA, 2022.
Abstract:
Arsenic (As), a naturally occurring element may induce oxidative stress and is a potent carcinogen. The present study aimed to find the lethal and sub-lethal concentration of arsenic trioxide and explore its effect on survival of fruit fly Drosophila melanogaster. Amelioration using polyphenols (curcumin and soya extract) have been introduced as a successful strategy to overcome this problem. The study showed significant decrease in lifespan of flies treated with arsenic trioxide. 50% mortality was seen in media with 0.5 mM arsenic trioxide and 100% mortality at 0.75 mM. Increased lifespan was observed in medium containing arsenic trioxide (0.55mM) with curcumin (Curcuma longa) and soya extract (Glycine max) respectively. Best survival rate was found in 0.55mM arsenic medium with 1 mM Curcumin and 1.5 mM Soya extract respectively. Lipid peroxidation assay showed significant increase in malondialdehyde (MDA) values in the flies treated with arsenic trioxide as compared to control. The MDA values decreased significantly in flies treated with arsenic mixed with curcumin and soya extract respectively. The results indicate that exposure to sub lethal concentration of arsenic trioxide may cause oxidative stress and affect the lifespan of D. melanogaster. Curcumin and soya extract may help in reducing the impact of oxidative stress and toxicity caused by arsenic trioxide.
Keywords: Arsenic trioxide; Curcuma longa; Glycine max; Lifespan; Oxidative stress
Comments on this paper
estefania Ascencio
3 January 2023
Dear authors thank you for your support to the conference.
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS'08 Brainstorming Workshop is Now Open from 2023-Jan-01 to 2023-Jan-31. MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide are ... Invited to Post Moderated Questions/Answers, Comments, about papers. Please kindly post your public Answers (A) to the following questions in order to promote interchange of scientific ideas. These are my Questions (Q) to you:
Q1. Apart from curcuma and soybean extract, are there any other compounds that reduce arsenic toxicity?
Thank you for your kind support. Please make questions to other papers in different Mol2Net congresses
Commenting Steps: Login, Go to Papers List, Select Paper, Write Comment, Click Post Comment
Papers list: https://mol2net-08.sciforum.net/presentations/view
Workshop link: https://mol2net-08.sciforum.net/#reviewwwers
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS'08 Brainstorming Workshop is Now Open from 2023-Jan-01 to 2023-Jan-31. MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide are ... Invited to Post Moderated Questions/Answers, Comments, about papers. Please kindly post your public Answers (A) to the following questions in order to promote interchange of scientific ideas. These are my Questions (Q) to you:
Q1. Apart from curcuma and soybean extract, are there any other compounds that reduce arsenic toxicity?
Thank you for your kind support. Please make questions to other papers in different Mol2Net congresses
Commenting Steps: Login, Go to Papers List, Select Paper, Write Comment, Click Post Comment
Papers list: https://mol2net-08.sciforum.net/presentations/view
Workshop link: https://mol2net-08.sciforum.net/#reviewwwers
Anjali Ranjan
5 January 2023
Apart from Curcuma and soya extarct, there are various other natural compounds and their derivatives that have been used to treat oxidative stress induced by As- toxicity. Such as Lamiaceae family representatives like- Ocimum sanctum leaf extract (Sharmila et al., 2009) Mentha piperita leaf extract (Sharma et al., 2007) etc. Green tea (Camellia sinensis) showed a chemopreventive effect for arsenic-H2O2-related oxidant stress in vitro (Acharyya et al., 2014) .Other natural compounds which shows positive effect in combating As- toxicity are Allium sativum (Garlic)(Adegboyega and Odunola,2012) and Zingiber officinale (Ginger) (Biswas et al., 2016).
Since prevention is better than cure, we should avoid drinking As-contaminated water and using such water for agriculture purpose.
References:
1. Sharmila Banu G., Kumar G., Murugesan A.G.(2009). Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem. Toxicol ;47:490–495. doi: 10.1016/j.fct.2008.12.004.
2. Sharma A., Sharma M.K., Kumar M.(2007). Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin. Pharmacol. Toxicol;100:249–257. doi: 10.1111/j.1742-7843.2006.00030.x.
3. Acharyya N., Chattopadhyay S., Maiti S.(2014). Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.;32:338–361. doi: 10.1080/10590501.2014.967061.
4. Adegboyega A., Odunola O.(2012). The modulatory effects of aqueous extracts of Viscum album and garlic on sodium arsenite induced toxicity in Wistar albino rat. J. Chem. Pharm. Res;4:4698–4701.
5. Biswas S, Maji C, Sarkar PK, Sarkar S, Chattopadhyay A, Mandal TK(2017). Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenic toxicity in calves. J Ethnopharmacol ;197:266-273. doi: 10.1016/j.jep.2016.07.079.
Since prevention is better than cure, we should avoid drinking As-contaminated water and using such water for agriculture purpose.
References:
1. Sharmila Banu G., Kumar G., Murugesan A.G.(2009). Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem. Toxicol ;47:490–495. doi: 10.1016/j.fct.2008.12.004.
2. Sharma A., Sharma M.K., Kumar M.(2007). Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin. Pharmacol. Toxicol;100:249–257. doi: 10.1111/j.1742-7843.2006.00030.x.
3. Acharyya N., Chattopadhyay S., Maiti S.(2014). Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.;32:338–361. doi: 10.1080/10590501.2014.967061.
4. Adegboyega A., Odunola O.(2012). The modulatory effects of aqueous extracts of Viscum album and garlic on sodium arsenite induced toxicity in Wistar albino rat. J. Chem. Pharm. Res;4:4698–4701.
5. Biswas S, Maji C, Sarkar PK, Sarkar S, Chattopadhyay A, Mandal TK(2017). Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenic toxicity in calves. J Ethnopharmacol ;197:266-273. doi: 10.1016/j.jep.2016.07.079.
Anjali Ranjan
5 January 2023
Apart from Curcuma and soya extarct, there are various other natural compounds and their derivatives that have been used to treat oxidative stress induced by As- toxicity. Such as Lamiaceae family representatives like- Ocimum sanctum leaf extract (Sharmila et al., 2009) Mentha piperita leaf extract (Sharma et al., 2007) etc. Green tea (Camellia sinensis) showed a chemopreventive effect for arsenic-H2O2-related oxidant stress in vitro (Acharyya et al., 2014) .Other natural compounds which shows positive effect in combating As- toxicity are Allium sativum (Garlic)(Adegboyega and Odunola,2012) and Zingiber officinale (Ginger) (Biswas et al., 2016).
Since prevention is better than cure, we should avoid drinking As-contaminated water and using such water for agriculture purpose.
References:
1. Sharmila Banu G., Kumar G., Murugesan A.G.(2009). Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem. Toxicol ;47:490–495. doi: 10.1016/j.fct.2008.12.004.
2. Sharma A., Sharma M.K., Kumar M.(2007). Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin. Pharmacol. Toxicol;100:249–257. doi: 10.1111/j.1742-7843.2006.00030.x.
3. Acharyya N., Chattopadhyay S., Maiti S.(2014). Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.;32:338–361. doi: 10.1080/10590501.2014.967061.
4. Adegboyega A., Odunola O.(2012). The modulatory effects of aqueous extracts of Viscum album and garlic on sodium arsenite induced toxicity in Wistar albino rat. J. Chem. Pharm. Res;4:4698–4701.
5. Biswas S, Maji C, Sarkar PK, Sarkar S, Chattopadhyay A, Mandal TK(2017). Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenic toxicity in calves. J Ethnopharmacol ;197:266-273. doi: 10.1016/j.jep.2016.07.079.
Since prevention is better than cure, we should avoid drinking As-contaminated water and using such water for agriculture purpose.
References:
1. Sharmila Banu G., Kumar G., Murugesan A.G.(2009). Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem. Toxicol ;47:490–495. doi: 10.1016/j.fct.2008.12.004.
2. Sharma A., Sharma M.K., Kumar M.(2007). Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin. Pharmacol. Toxicol;100:249–257. doi: 10.1111/j.1742-7843.2006.00030.x.
3. Acharyya N., Chattopadhyay S., Maiti S.(2014). Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.;32:338–361. doi: 10.1080/10590501.2014.967061.
4. Adegboyega A., Odunola O.(2012). The modulatory effects of aqueous extracts of Viscum album and garlic on sodium arsenite induced toxicity in Wistar albino rat. J. Chem. Pharm. Res;4:4698–4701.
5. Biswas S, Maji C, Sarkar PK, Sarkar S, Chattopadhyay A, Mandal TK(2017). Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenic toxicity in calves. J Ethnopharmacol ;197:266-273. doi: 10.1016/j.jep.2016.07.079.
