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In vivo antigenotoxic properties of Hericium erinaceus ethanolic extract
* 1 , 2 , 3 , 4 , 5
1  University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia
2  Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
3  Innovation Centre of the Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
4  Faculty of Occupational Safety, University of Niš. Čarnojevića 10a, 18000 Niš, Serbia
5  Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
Academic Editor: Maria Emília Sousa

Published: 26 September 2022 by MDPI in 8th International Electronic Conference on Medicinal Chemistry session General (registering DOI)

Hericium erinaceus (Bull.) Pers., also known as lion’s mane or monkey’s head, is a well-established culinary and medicinal mushroom used traditionally against dementia, depression, anxiety, ulcers, heart disease, cancer, and diabetes in animals. This mushroom with a variety of health benefits has strong anti-inflammatory, antioxidant and immune-boosting abilities. Ethanolic extract of the cultured fruiting bodies of H. erinaceus were investigated for antigenotoxic activity against ethyl methanesulphonate (EMS)-induced genotoxicity in third instar larvae of Drosophila melanogaster using alkaline comet assay. A simultaneous 24-h treatment with seven different concentrations of the extract (1.25, 2.5, 5, 10, 20, 40, and 80 mg/mL standard Drosophila food) and 1 mM EMS, show decreased in total comet score compared to positive control. The results showed that the ethanolic extracts of H. erinaceus have a remarkable DNA protective activity against EMS-induced DNA damage, suggesting that this mushroom has potential to be used as a natural preventive compound against DNA damage caused by monofunctional alkylating agents such as EMS.

Keywords: Hericium erinaceus; antigenotoxic; Drosophila melanogaster, comet assay