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Selected biomarkers of oxidative stress in ischemic stroke.
1 , * 2 , 3 , 4 , 5 , 1 , 6 , 3 , 7 , 1
1  Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Medicine, Department of Medical Biology and Biochemistry, Karłowicza 24, 85–092 Bydgoszcz, Poland
2  Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85–092 Bydgoszcz, Poland
3  Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Health Sciences, Department of Cardiology and Clinical Pharmacology, Ujejskiego 75, 85-168 Bydgoszcz, Poland
4  Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Health Sciences, Department of Geriatrics, Division of Biochemistry and Biogerontology, Dębowa 3, 85-626 Bydgoszcz, Poland
5  Medical Stimulation Center, Medical University of Gdańsk, Gdańsk, Poland
6  University College London, Centre for Languages & International Education, 26 Bedford Way London WC1H 0AP, United Kingdom
7  Department of Neurology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland
Academic Editor: Alfredo Berzal-Herranz

Abstract:

Stroke is a serious health problem all over the world and the second, after the heart attack, cause of death and permanent disability in people. Oxidative stress plays an important role in the pathogenesis of ischemic stroke (AIS).

The aim of our study was to evaluate the temporal profile of the melatonin metabolite 6-hydroxymelatonin sulphate (6-SM) in the urine and carbonyl groups in the serum of patients with acute ischemic stroke treated with intravenous thrombolysis.

There were statistically significant differences between the values of 6-SM and carbonyls compared to the control group. Statistical differences were also found in the concentrations of the examined parameters depending on the type of stroke. The studies revealed the correlations between the concentrations of 6-SM and the carbonyl groups measured in various time intervals and between the concentration of biomarkers and mortality was also evaluated.

The obtained results may indicate an increased oxidative stress, and the intense increase in the concentration of carbonyl groups in patients with AIS may be considered a potential marker of protein damage in thrombolytic patients. Melatonin supplementation in AIS patients can also be considered, as it can effectively prevent both behavioral and neurophysiological defects caused by cerebral hypoxia and ischemia.

Keywords: ischemic stroke; biomarkers, melatonin, carbonyl group
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