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Synthesis of novel 2-phenylindole analogues as antifungal and antibacterial agents
Published:
01 November 2022
by MDPI
in 8th International Electronic Conference on Medicinal Chemistry
session Small molecules as drug candidates
Abstract:
A series of novel indole derivatives containing ester groups, halogen, epoxy and short-chain aliphatic hydrocarbons were designed, synthesized and evaluated for their antibacterial activities. Most of the compounds showed relatively excellent inhibitory activities against different strains (including a multidrug-resistant clinical isolate). Compounds 1f, 1o and 1r showed the strongest inhibitory activity (mic of 2-32 μg/ml). Compounds 1f, 1h, 1i, 1o and 1r with antibacterial activity were not cytotoxic against RAW 264.7 mouse macrophages. Structure-activity relationship analysis and docking studies showed that halogens as well as aliphatic hydrocarbons could enhance the antibacterial ability and reduce the toxicity of the indole compounds
Keywords: Synthesis; anti-bacterial; anti-fungal; 2-phenylindole
Comments on this paper
pan xinhui
26 November 2022
interesting work
Ke Yang
26 November 2022
In this paper, we optimized the synthesis process to make it more rapid, cleaned and tested the drug-resistant Candida albicans and found that the activity of some compounds was superior to fluconazole. Moreover, the 2-phenylindoles were found to have good broad-spectrum activity when tested against sensitive strains, which provides an important reference for scholars on the structural modification of 2-phenylindoles.
xiaoying sun
26 November 2022
This article is rich in content, very beneficial to me, is worth learning.
Guanzhong Chen
26 November 2022
Interesting way of synthesizing 2-phenylindoles, and provide a new ideas for the synthesis of drug-resistant antifungal drugs
Caiyun Yang
26 November 2022
The content of this study is substantial and thestructure is novel, which provides an excellentresearch idea for researchers.
MAN TENG
26 November 2022
This paper provides new ideas for the synthesis of drug-resistant antifungal drugs
Guanzhong Chen
26 November 2022
Interesting way of synthesizing 2-phenylindoles, and provide a new ideas for the synthesis of drug-resistant antifungal drugs
Qiaohui Liu
26 November 2022
To provide reference for the synthesis of resistant antifungal drugs
li guo
26 November 2022
This paper provides an important reference for scholars on the structural modification of 2-phenylindoles.
