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Interactionts between heterometallic bridged cis-or trans-Pt(II)-Zn(II)complexes and calf thymus DNA
1 , 2 , 3 , 4 , 5 , * 6
1  Department of Science, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, Kragujevac 34000, Serbia
2  Institute for Information Technologies, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia
3  University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, 34000 Kragujevac, Serbia
4  University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, 34000 Kragujevac, Serbia
5  Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia
6  Department of Natural-Mathematical Sciences, State University of Novi Pazar, Vuka Karadžića bb, 36300 Novi Pazar, Serbia
Academic Editor: Alfredo Berzal-Herranz (registering DOI)

More recently scientific attention is paid on non-platinum based drug especially on bio-essential metal ions. Design of the heterometallic complexes is possible way to overcome limitation of platinum-based drugs.
The four novel complexes [{cis-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2, [{trans-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2, [{cis-PtCl(NH3)(μ-pyrazine)ZnCl(terpy)}](ClO4)2 and [{trans-PtCl(NH3)(μ-pyrazine)ZnCl(terpy)}](ClO4)2 (where terpy = 2,2′:6′,2′′-terpyridine) were synthesized and characterized. The binding of the heterometallic bridged cis-or trans-Pt(II)-Zn(II) complexes to calf thymus DNA (CT-DNA) was studied using UV absorption and fluorescence emission spectroscopy. The results indicate that the complexes bind strongly to DNA (Kb, in the order of 104 M−1) through groove binding, hydrogen bonds, and hydrophobic or electrostatic interaction. According to Stern–Volmer quenching constant (KSV) and binding constant (K), the [{cis-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2 complex interacts with CT-DNA-EB more strongly than the rest of the studied complexes.

Keywords: zinc(II); platinum(II); DNA interactions; heterometalic complexes;