In northern Thailand, devastating landslides and debris flow frequently occur after heavy rainfalls. This study focused on the evaluation of debris flow using the DFLOWZ and Debris-2D models. The data collected from the failure at Santisuk-Bo Kluea (No. 1081) road on 27 July 2018 were used to validate the model results. The total debris flow volume that occurred at the Santisuk-Bo Kluea (No. 1081) road was estimated using the Digital Elevation Model (DEM) analysis. The actual deposition and affected areas were depicted using aerial photos to validate simulated deposition areas. As a result, it is indicated that the DFLOWZ model provides a better agreement compared to the actual deposited area. It was found that the differences in the deposition area and the overlapping deposition area obtained from the DFLOWZ model are 16% and 34%, respectively. For the Debris-2D model with the minimum yield stress of 8000 Pa, the differences in the deposition area and the overlapping deposition area are 51% and 16%, respectively. It should be noted that prudential input parameters should be selected with caution. Especially, the yield stress, which is the main factor for the Debris-2D model, should be obtained from the testing suggested by Liu and Huang (2006)