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A photolabile amino acid building block based on a new fluorescent functionalised coumarin-6-yl-alanine
Published: 30 October 2009 by MDPI in The 13th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A new fluorescent functionalized amino acid, 4-chloromethylcoumarin-6-yl-alanine, was used in the synthesis of an amino acid conjugate by coupling with a model N-protected alanine, through an ester linkage. The photophysical properties of the fluorescent conjugate are presented, as well as its behaviour towards photocleavage by irradiation in methanol/HEPES buffer (80:20) solution, in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV and 1H NMR monitoring.
Keywords: Coumarin-6-yl-alanine; Amino acid conjugates; Photochemical cleavage