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Synthesis and Fluorescent Properties of 2-Amino Substituted 6,7-Dimethoxy-4-trifluoromethyl-quinolines
Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: 2-Amino substituted 6,7-dimethoxy-4-trifluoromethyl-quinolines were synthesized from the 2-oxo derivatives by chlorination with phosphoryl chloride and aminated with 4-aminobenzoate to give a highly fluorescent molecule suitable for linking to appropriate biomolecules and biopolymers. The linking was achieved by conversion of the benzoate to reactive O-succinimide esters, which react easily with amino groups of biomolecules such as amino acids, aminosugars and the related biopolymers. The investigation of the fluorescent properties show pH independent properties and large Stokes shifts, however a rather low quantum yield.