Synthesis of Novel Coumarin Based Fluorescent Probes

Ivana Kosiova; Pavol Kois

doi:10.3390/ecsoc-10-01398

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Synthesis of Novel Coumarin Based Fluorescent Probes

Ivana Kosiova

^*,

Pavol Kois

¹ Comenius University, Faculty of Natural Sciences, Department of Organic Chemistry, Mlynska dolina, Pavilon CH2, SK-84215 Bratislava, Slovak Republic

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-10-01398

Abstract: We report on synthesis of new fluorescent probes suitable for site specific incorporation into oligonucleotides. Coumarin derivatives (1-5) were used as sensitive fluorescent labels and two linkers (6-7) were attached to the basic coumarin skeleton for further applications. Spectral characteristic of functionalized coumarin derivatives (8-10,13-14) were measured and derivative with the best fluorescent properties was chosen. Phosporamidite derivative 17 was prepared from functionalized coumarin derivative 9.

Keywords: coumarin, labeling, phosphoramidite, oligonucleotide

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Ivana Kosiova

Pavol Kois