The purpose of this review is to delve into the essence of Annona muricata Linn. , also known as Soursop, Guanabana, and Graviola which is a member of the Annonaceae family and has a long history of traditional uses. This evergreen plant grows in tropical and subtropical regions of the world, primarily in Africa, South America, and Southeast Asia. The A. muricata plant's miraculous nature is a boon to mankind and has been widely used in folk medicine. A. muricata preparations on the market include candies, syrups, beverages, ice creams, and shakes. Several studies have concluded that the plant contains over 212 chemical constituents such as acetogenins, alkaloids, and phenols. The plant has antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inflammatory, immune-enhancing effects, and anti-diabetic activity. Although some toxicities have been reported, the extract of A. muricata is effective and safe. This review attempts to bring together the majority of the available information on A. muricata phytochemistry, traditional uses, biological activities, and toxicity.