Microwave-assisted Reactions of Substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their Biological Activity

Alžbeta Krutošíková; Katarína Kráľová; Daniel Zbojek; Martin Moncman; Renata Gašparová

doi:10.3390/ecsoc-10-01436

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Microwave-assisted Reactions of Substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their Biological Activity

Alžbeta Krutošíková

¹,

Katarína Kráľová

²,

Daniel Zbojek

¹,

Martin Moncman

¹,

Renata Gašparová

^{*

1}

¹ Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie Jozefa Herdu 2, Sk-917 01 Trnava, Slovakia
² Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2,

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Symposium on Microwave Assisted Synthesis

https://doi.org/10.3390/ecsoc-10-01436

Abstract: The microwave-assisted reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5-substituted furan-2-carboxaldehydes 2, thiophene-2-carboxaldehyde 3 and 2-formyl-4-methylfuro[3,2-b]pyrrole-5-carboxylate 4 have been studied under microwave irradiation. Reactions of 1 with 4-substituted 1,3-oxazol-5(4H)-ones 8 led to imidazole derivatives 9. The effects of hydrazones 5-7 on inhibition of photosynthetic electron transport in spinach chloroplasts were investigated.

Keywords: furo[3,2-b]pyrrole-5-carboxhydrazide, furan-2-carboxaldehyde, thiophene-2-carboxaldehyde, 2-formyl-4-methylfuro[3,2-b]pyrrole-5-carboxylate, microwave irradiation

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Alžbeta Krutošíková

Katarína Kráľová

Daniel Zbojek

Martin Moncman

Renata Gašparová